中国药物警戒 ›› 2013, Vol. 10 ›› Issue (9): 557-559.

• 药械安全性研究 • 上一篇    下一篇

241例林可霉素致不良反应文献分析

陈兴莉1,连诗桃2,杜艳3,韩达斌1,程小平1   

  1. 1.青海省药品不良反应监测中心,青海西宁810007；
    2.西宁市中庄小学,青海西宁810006；
    3.武警四川森林总队门诊部,四川成都610041
  • 收稿日期:2013-02-26 修回日期:2016-03-09 出版日期:2013-09-08 发布日期:2016-03-09
  • 作者简介:陈兴莉,女,硕士,主管药师,药品不良反应及医疗器械不良事件监测。

Literature Analysis of 241 Cases of Adverse Drug Reactions Induced by Lincomycin

CHEN Xing-Li1 ,LIAN Shi-tao2 ,DU-Yan3 ,HAN Da-bin1, CHENG Xiao -ping1   

  1. 1.Qinghai Center for Drug Reevaluation, Qinghai Xining 810007, China;
    2.Xining Zhongzhuang Primary School, Qinhai Xining 810006, China;
    3.Outpatient Department of Sichuan Forest Division of Chinese People's Armed Police Force Sichuan Chengdu 610041, China
  • Received:2013-02-26 Revised:2016-03-09 Online:2013-09-08 Published:2016-03-09

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摘要： 目的 探讨林可霉素致不良反应的一般规律特点,为临床合理用药提供参考。方法 对1995～2013年中国期刊全文数据库文献进行检索,有关林可霉素致不良反应241 例个案报道进行回顾性分析。结果与结论 林可霉素致不良反应与剂量过大、滴速和给药途径等有关,不良反应多发生在用药初期,临床应加强应用监测,确保用药安全。

关键词: 林可霉素, 不良反应, 文献分析

Abstract: Objective To study the characteristics and regular patterns of adverse drug reactions(ADR) caused by lincomycin, and to provide a reference for clinical rational use of the drugs. Methods By searching literature in Chinese Journal Full-text Database from 1995 to 2013, 146 case reports of adverse drug reactions induced by lincomycin were analyzed retrospectively. Results and Conclusion Lincomycin inducing adverse reaction might be relevant to overdose, drip rate and route of administration, and so on. ADRs mostly occurred in the early stage of the drug administration. Monitoring should be strengthened clinical application to ensure drug safety.

Key words: lincomycin, adverse drug reaction, literature analysis

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