中国药物警戒 ›› 2013, Vol. 10 ›› Issue (9): 560-562.

• 药械安全性研究 • 上一篇    下一篇

97例注射用磷霉素钠不良反应文献分析

汤韧,高艳,范燕*   

  1. 国家食品药品监督管理局药品评价中心,北京 100045
  • 收稿日期:2013-08-26 修回日期:2016-03-09 出版日期:2013-09-08 发布日期:2016-03-09
  • 通讯作者: 范燕,女,硕士,药理学及药品不良反应监测与评价。 E-mail: fanyan@cdr.gov.cn
  • 作者简介:汤韧,男,本科,工程师,药品不良反应监测与评价。

Literature Analysis of 97 Cases of Adverse Drug Reaction Induced by Fosfomycin Sodium

TANG Ren ,GAO Yan ,FAN Yan*   

  1. Center for Drug Reevaluation, SFDA, Beijing 100045, China
  • Received:2013-08-26 Revised:2016-03-09 Online:2013-09-08 Published:2016-03-09

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摘要： 目的 探讨注射用磷霉素钠所致不良反应的一般规律和特点,以期为临床安全用药提供参考。方法 以“注射用磷霉素”并含“不良反应”为主要检索词,检索中国知网（CNKI）数据库1980 年1 月～2013 年1 月间报道的涉及注射用磷霉素钠所致不良反应的文献报道,分别从不良反应的发生时间、原患疾病、临床表现及预后等方面进行统计分析。结果 共检索出33 篇97 例病例,不良反应累及系统- 器官以皮肤及其附件损害为最多、其次为呼吸系统损害、全身性损害和心血管系统一般损害；主要临床表现为瘙痒、皮疹、呼吸困难、胸闷等；多数不良反应在停药或对症治疗处理后恢复正常。结论 注射用磷霉素钠的不良反应累及系统- 器官较少,不良反应预后良好,但临床仍应重视注射用磷霉素钠的不良反应,加强用药监测,确保用药安全。

关键词: 磷霉素, 药品不良反应, 文献分析

Abstract: Objective To analyze the general characteristics of adverse drug reaction induced by fosfomycin sodium, provide reference for rational drug use in clinic. Methods Using "fosfomycin sodium" and "adverse drug reaction" as the keywords, searched the cases of the adverse drug reaction induced by fosfomycin sodium which were reported from Jan 1980 to Jan 2013. The data were analyzed in terms of occurrence time, original disease, clinical manifestation, prognosis, et al. Results There were 33 publications including 97 cases. Skin and appendages disorders were with the highest incidence, followed by the respiratory system disorders, systematic disorders and cardiovascular disorders. The main clinical manifestations were pruritus, rash, dyspnea, sense of suppression in the chest, et al. Most of adverse drug reactions got right after drug withdrawal and symptomatic treatment. Conclusion The adverse drug reactions induced by fosfomycin sodium were low, and prognosis was well. Attention should be paid to the adverse drug reactions induced by fosfomycin sodium in clinic, and the monitoring of medication should also be strengthened to ensure the safe medication.

Key words: fosfomycin, adverse drug reaction, literature analysis

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