中国药物警戒 ›› 2013, Vol. 10 ›› Issue (9): 545-548.

• 综述 • 上一篇    下一篇

与功效和毒性相关的柴胡化学成分研究进展

黄伟1,吕征2,孙蓉1*   

  1. 1.山东省中医药研究院,山东济南250014；
    2.山东中医药大学,山东济南250355
  • 收稿日期:2012-08-06 修回日期:2016-03-09 出版日期:2013-09-08 发布日期:2016-03-09
  • 通讯作者: 孙蓉,女,研究员·博导,博士,中药药理与毒理。E-mail:sunrong107@163.com
  • 作者简介:黄伟,男,实习研究员,硕士,中药药理与毒理。
  • 基金资助:
    国家重点基础研究发展计划（973）中医基础理论专项资助项目（2009CB522802）；国家自然科学基金项目（81374059）；国家自然科学基金项目（30672649）；国家自然科学基金项目（81073148）；山东省科技平台建设项目（2008GG2NS02021）；山东省科技公关关键技术研究课题（2007GG2NS02073）；山东省科技平台建设项目课题（2008GG2NS02021）。

Research Development on Chemincal Compositions in Related with Efficacy and Toxicity

HUANG Wei1, LV Zheng2 ,SUN Rong1*   

  1. Shandong Academy of Traditional Chinese Medicine, Shandong Jinan 250014, China;
    2.Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China
  • Received:2012-08-06 Revised:2016-03-09 Online:2013-09-08 Published:2016-03-09

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摘要： 目的 总结与功效和毒性相关的柴胡化学成分研究现状,明确柴胡的功效成分与毒性成分,为进一步研究柴胡化学成分与功效、毒性间的相关性提供文献依据和思路。方法 对近 20年来国内外发表的相关文献进行分析、整理和归纳。结果 柴胡的主要化学成分是柴胡皂苷、挥发油、黄酮类、多糖和植物甾醇等,其中皂苷类和挥发油类是柴胡的主要化学成分；柴胡的药理活性研究主要集中在皂苷类、挥发油、黄酮类和多糖；柴胡毒性研究主要集中在柴胡提取物、皂苷类和挥发油,其毒性靶器官主要为肝脏。结论 柴胡皂苷类和挥发油类成分既是柴胡保肝作用的有效成分,又是其产生肝毒性的成分,如何最大化的发挥其“疏肝解郁”的功效,限制其“柴胡劫肝阴”肝毒性的产生,是目前制约柴胡化学成分研究的关键。对于柴胡的功效和毒性研究应放在中医证侯的背景下进行综合评价和科学认知,探讨其“有效治疗窗”和“药物安全窗”,以保证临床用药的安全、有效。

关键词: 柴胡, 化学成分, 功效, 毒性

Abstract: Objective By combing pertinent literature and summarizing the current states of chemical composition of Bupleurum Chinense related with its efficacy and toxicity, to identify its effective and toxical composition, offer the accordance and research ideas for further research on the relationship between efficacy, toxicity and chemical composition of Bupleurum Chinense. Methods The related references in recent 20 years at home and abroad about Bupleurum Chinense were analyzed, collated and summarized. Results The main chemical composition of was saikosaponin, naphtha, flavonoids, polysaccharide and plant sterol, etc, and the saikosapoin and naphtha were the main chemical compositions; the pharmacological activity research was focused on saikosaponin, naphtha, flavonoids and polysaccharide; the toxicity research was focused on the extracts of , saikosaponin and naphtha, and the toxical target organ was liver. Conclusion The saikosaponin and naphtha were not only effective compositions that protected the liver, but also the toxical composition that injured of the liver. How to maximize the "shuganjieyu" efficacy and limit the hepatotoxicity of "Chinense robbing hepatic yin" were the key that restricted the chemical composition research. The efficacy and toxicity research of should be put on the background of traditional Chinese medicine syndrome to make the comprehensive evaluation and scientific cognitive, to explore the "effective treatment window " and "drug safety window", and to insure the safety and effectiveness of clinical medication.

Key words: chemical composition, efficacy, toxicity

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