中国药物警戒 ›› 2013, Vol. 10 ›› Issue (1): 36-38.

• 综述 • 上一篇    下一篇

基于功效和毒性的细辛化学成分研究进展

王懿12,黄伟1,孙蓉1   

  1. 1.山东省中医药研究院,山东济南250014；
    2.山东中医药大学,山东济南250355
  • 收稿日期:2011-04-11 修回日期:2016-03-12 出版日期:2013-01-08 发布日期:2016-03-09
  • 通讯作者: 孙蓉,女,研究员,博士生导师,中药药理与毒理。E-mail：sunrong107@163.com
  • 作者简介:王懿,女,在读硕士,中药药理与毒理。
  • 基金资助:
    国家973计划中医基础理论专项课题（2009CB322802）。

Research Development on Chemical Compositions of Asarum Based on Efficacy and Toxicity

WANG Yi1,2 ,HUANG Wei1, SUN Rong1   

  1. 1.Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    2. Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China
  • Received:2011-04-11 Revised:2016-03-12 Online:2013-01-08 Published:2016-03-09

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摘要： 目的 通过梳理相关文献,总结与功效、毒性相关的细辛化学成分研究现状,明确细辛的功效成分与毒性成分,为进一步研究细辛化学成分与功效、毒性间的相互关系提供依据和思路。方法 对近30年来国内外发表的相关文献进行分析、整理和归纳。结果 细辛主要化学成分为挥发油类、非挥发油类、马兜铃酸类化合物,挥发油类物质中的甲基丁香酚是主要功效物质基础,马兜铃酸Ⅰ是主要毒性物质基础。结论 细辛的化学成分研究应注重与细辛的功效和毒性相关联,也应注意产生功效与导致毒性的物质基础的异同,从而分析不同物质基础下作用性质的差异,同时还要结合中医辨证论治与辨病论治的背景,注重在证候背景下功效和毒性反应的物质基础研究。

关键词: 细辛, 功效, 毒性, 化学成分

Abstract: Objective By combing pertinent literature and summarizing the current states of chemical compositions of Asarum related with its efficacy and toxicity, identify its effective and toxic composition, and offer the accordance and research ideas for further research on the relationship among efficacy, toxicity and chemical composition of Asarum . Methods The related references in recent 30 years both at home and abroad about Asarum were analyzed, collated and summarized. Results Volatile oil、non -volatile oil and the aristolochinc acid compounds are the main chemical compositions of . Methyl eugenol from volatile oil is the main effective material basis and aristolochic acid I is the main toxic material basis. Conclusion The research on the chemical composition of Asarum should be laied stress on the connection with efficacy and toxicity, and the similarities and differences between the effective material basis and the toxical material basis should be paid attention to, so as to analyze the effective essence differences based on material basis. In addition, we should lay emphasis on the effective and toxic material basis on the background of syndrome by combining "treatment based on syndrome differentiation" and "treatment treatment based on disease differentiation" in Traditional Chinese Medicine.

Key words: Asarum , efficacy, toxicity, chemical composition

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