药品不良反应信号检测中遮蔽效应的影响及消除方法

中国药物警戒 ›› 2013, Vol. 10 ›› Issue (1): 33-35.

药品不良反应信号检测中遮蔽效应的影响及消除方法

叶小飞¹,程刚²,郭晓晶¹, 许金芳¹,贺佳¹

1.第二军医大学卫生统计学教研室,上海200433；
2.国家药品不良反应监测中心,北京100045

收稿日期:2012-01-05 修回日期:2016-03-12 出版日期:2013-01-08 发布日期:2016-03-09
通讯作者: 贺佳,女,博士生导师,药物流行病学及新药评价的统计分析。E-mail：hejia@smmu.edu.cn
作者简介:叶小飞,男,讲师,药物流行病学。
基金资助:
国家自然科学基金资助项目（No. 30872186,No.81072388,No.81202285）,上海市自然科学基金资助项目（12ZR1453700）,上海市优秀学科带头人计划（A 类）（No.09XD1405500）,2010年上海市领军人才计划（022）,上海市循证公共卫生重点学科（12GWZX0602）

Masking Effect in the Process of Signal Detection of Adverse Drug Reaction

YE Xiao-fei¹, CHENG Gang², GUO Xiao-jing¹, XU Jin-fang¹, HE Jia^1*

1.Department of Health Statistics, Second Military Medical University, Shanghai 200433, China;
2.National Center for ADR Monitoring, Beijing 100045, China

Received:2012-01-05 Revised:2016-03-12 Online:2013-01-08 Published:2016-03-09

摘要/Abstract

摘要： 常规的药品不良反应信号检测方法基于不相称测定理论,在药品不良反应监测中发挥着重要的作用。然而这些方法在信号检测准确性中存在一些缺陷,无法很好地解决一些现象,如遮蔽效应等。这些现象需要基于新的策略对数据进行分析,本文介绍遮蔽效应对信号检测准确性的影响,以及如何发现和消除遮蔽效应的研究进展。

关键词: 遮蔽效应, 药品不良反应, 信号检测

Abstract: Routine adverse drug reaction signal detection Methods based on disproportionality analysis are playing important role in the process of adverse drug reaction surveillance. However, these Methods have their own drawbacks in the accuracy for signal detection and could not solve some problems which include masking effect. These problems should be solved through new analysis strategy. In this article, we present the impact of masking effect on the signal detection and introduce the latest research on the identification and elimination of masking effect.

Key words: masking effect, adverse drug reaction, signal detection

中图分类号:

R954

叶小飞,程刚,郭晓晶, 许金芳,贺佳. 药品不良反应信号检测中遮蔽效应的影响及消除方法[J]. 中国药物警戒, 2013, 10(1): 33-35.

YE Xiao-fei, CHENG Gang, GUO Xiao-jing, XU Jin-fang, HE Jia . Masking Effect in the Process of Signal Detection of Adverse Drug Reaction [J]. Chinese Journal of Pharmacovigilance, 2013, 10(1): 33-35.

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