基于功效和物质基础的山豆根毒性研究进展

中国药物警戒 ›› 2011, Vol. 8 ›› Issue (2): 105-107.

基于功效和物质基础的山豆根毒性研究进展

吕莉莉¹, 谢元璋², 孙蓉¹

1. 山东省中医药研究院,山东济南 250014;
2. 哈尔滨商业大学,黑龙江哈尔滨 150000

收稿日期:2015-08-27 修回日期:2015-08-27 出版日期:2011-02-10 发布日期:2015-08-27
通讯作者: 孙蓉,女,研究员,硕士生导师,中药药理与毒理研究。E-mail：sunrong107@163.com
作者简介:吕莉莉,女,副研究员,中药药理与毒理研究。
基金资助:
山东省科技平台建设项目（2008GG2NS02021）;国家重点基础研究发展计划（973）中医基础理论专项资助项目（2009CB522802）

Research Progress on Toxicity of Sophora Tonkinensis Based on Efficacy and Material Basis

LV Li-li¹, XIE Yuan-zhang², SUN Rong¹

1. Shandong Research Academy of TCM, Shandong Jinan 250014, China;
2. Harbin University of Commerce, Heilongjiang Harbin 150000, China

Received:2015-08-27 Revised:2015-08-27 Online:2011-02-10 Published:2015-08-27

摘要/Abstract

摘要： 目的总结与山豆根的功效、毒性相关的物质基础研究现状,明确山豆根的功效成分和毒性成分,为进一步研究山豆根功效与毒性的相关性提供文献依据和研究思路。方法对山豆根近30年来相关文献进行整理、分析与归纳。结果药典与现代文献均记载山豆根有毒,苦参碱是产生毒性的主要成分。关于山豆根的体内毒性过程、毒性作用特点、作用机制尚未见报道,也未见关于山豆根发挥功效和产生毒性的剂量范围研究报道。结论关于山豆根的规范毒性研究尚不完善,尤其是以功效和物质基础为背景的毒性研究尚属空白,亟待进行符合中医药特色的山豆根毒性认知研究,以期为临床合理用药提供实验依据和文献思路。

关键词: 山豆根, 功效, 物质基础, 毒性

Abstract: Objective To identify its effective and toxical composition, offer the accordance and study ideas for further research on the relationship between efficacy, toxicity and material foundation of Sophora tonkinensis, by summarizing the current states of material foundation of Sophora tonkinensis related with its efficacy and toxicity. Methods The published references of Sophora tonkinensis were collected, analysised and summarized in the recent 30 years. Results The obvious toxicial effects have been reported of Sophora tonkinensis in Pharmacopoeia and current references, although there is no obvious toxicial effects have been recorded in angent books, such as<Shen nong Ben Cao Jing>,<Ben Cao gang mu>et. The main toxical systems and signs were nausea, diarrhea, chest distress and cardiopalmus. The chemical material foundation, process in vivo, characters and mechanism of toxical effect even though the dosage ranges of efficacy and toxicity have not been reported yet, and investgated regularly. Conclusion There is little perfect study reports of Sophora tonkinensis related to its toxicity, especially the toxicial study based on the efficacy and material foundation. It's urgent that the toxicity of Sophora tonkinensis related to the characteristics of TCM to be identified correctly and studied scientifically in order to provide experimental data, investgating ideas and evidences for the good use in clinic.

Key words: Sophora tonkinensis, efficacy, material base, toxicity

中图分类号:

R282

吕莉莉, 谢元璋, 孙蓉. 基于功效和物质基础的山豆根毒性研究进展[J]. 中国药物警戒, 2011, 8(2): 105-107.

LV Li-li, XIE Yuan-zhang, SUN Rong. Research Progress on Toxicity of Sophora Tonkinensis Based on Efficacy and Material Basis[J]. Chinese Journal of Pharmacovigilance, 2011, 8(2): 105-107.

参考文献

[1] 张涛.山豆根药理作用与临床应用研究近况[J].广西中医学院学报,2008,11(3):110.
[2] 李希新.山豆根的研究概况[J].山东中医药大学报,2000,24(3):235-237.
[3] 张明武.山豆根中毒的临床观察[J].新中医,1988,20(5):55.
[4] 尤荣开.山豆根中毒15例报道[J].临床荟萃,1997,12(13):13.
[5] 胡纪源,陆松,何光远,李凯,等.山豆根中毒致亚急性坏死性基底节脑病6例[J].安徽中医学院学报,2002,21(3):20-22.
[6] 李凯,杨任民,范玉新.山豆根中毒引起亚急性基底节坏死性脑病2例报告[J].中国中西医结合杂志,1995,15(6):封三.
[7] 杨光.临床药用豆根要区分南北[J].北京中医,1983, (4):56.
[8] 谭成明,房慧伶,胡庭俊.山豆根生物活性成分及药理作用的研究进展[J].广西农业科学,2009,40(11):1494-1496.
[9] 窦金辉,李家实,阎文玫.山豆根生物碱成分的研究[J].中国中药杂志,1989,5(19):40-42.
[10] Komatsu M,Yokoe I,Shirataki Y.Studies on the con-stituents of sophora species.Ⅻ.Constituents of the aerialparts of Sophora tome- ntosa L[J].Chem Pharm Bull,1978,26(4):1274-1278.
[11] 高雪娥,杨汉辉.山豆根毒副作用探讨[J].福建医药杂志,1999,21(4):100.
[12] 天津市药品检验,药物研究所药检室.山豆根中毒66例分析[J].天津医药,1976, (9):423.
[13] 赵培荣,田爱琴,马湘玲,等.山豆根对人食管癌细胞株(Eca-109)杀伤、抑制及脱氢酶类影响[J].河南肿瘤学杂志,1998,11(2):87-89.
[14] 姚仲青,朱虹,王光凤.山豆根总生物碱抗肿瘤作用的初步研究[J].南京中医药大学学报,2005,21(4):253-254.
[15] 谢世荣,黄彩云,黄胜英.山豆根碱抗炎作用的研究[J].中草药,2003,34(4):355-357.
[16] 陈小松,王国俊,蔡雄,等.氧化苦参碱对乙型肝炎病毒转基因小鼠乙肝抗原表达的影响[J].第二军医大学学报,1999,20(10):746-748.
[17] 张红菱.氧化苦参碱对四氯化碳损伤大鼠肝细胞的保护作用[J].郧阳医学院学报,2002,21(5):273-275.
[18] 廖杰,张宝恒.氧化苦参碱的抗炎症作用[J].北京医科大学学报,1998,22(4):313.
[19] 孙蓉,杨倩,赵燕.山豆根不同组分小鼠急毒性比较研究[J].中国药物警戒,2010,7(5):257-262.
[20] 孙蓉,杨倩,郑丽娜,等.山豆根不同组分小鼠急性肝毒性“量-时-毒”关系研究[J].中国药物警戒,2010,7(7):385-389.
[21] 丁佩兰,陈道峰.中药山豆根及其制剂的药理作用、临床应用于不良反应[J].中国临床药学杂志,2003,12(5):315-317.
[22] 孙蓉,黄伟,鲍志烨,等.基于功效和物质基础的半夏毒性研究进展[J].中国药物警戒,2010,7(1):37-40.