[1] Chinese Pharmacopoeia Commission.Pharmacopoeia of the People's Republic of China(中华人民共和国药典)[S]. Beijing: China Medical Science and Technology Press, 2020. [2] Compilation group of national collection of Chinese herbal medicines. National compilation of Chinese herbal medicine(全国中草药汇编)[M]. Beijing: People's Health Publishing House, 2014. [3] ZHANG W, REN K, REN SM, et al.UPLC-Q-Exactive-MS analysis for hepatotoxicity components of Evodiae Fructus based on spectrum-toxicity relationship[J]. Journal of Chromatography B, 2021, 1176: 122772. [4] WU CT, WANG X, XU M, et al.Intracellular accumulation as an indicator of cytotoxicity to screen hepatotoxic components of chelidonium majus L. by LC-MS/MS[J]. Molecules, 2019, 24(13): 2410. [5] FENG Q, YAO JC, LI X, et al.Network analysis and mechanism prediction of cardiotoxicity caused by alkaloids from Radix Aconiti[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2022, 19(1): 62-68. [6] ZHAO DS, WU ZT, LI ZQ, et al.Liver-specific metabolomics characterizes the hepatotoxicity of Dioscorea bulbifera rhizome in rats by integration of GC-MS and 1 H-NMR[J]. Journal of Ethnopharmacology, 2018, 226:111-119. [7] YUAN ZQ, YUAN ZH, MUHAMMAD H, et al.A new perspective of triptolide-associated hepatotoxicity: the relevance of NF-κB and NF-κB-mediated cellular FLICE-inhibitory protein[J]. Acta Pharmaceutica Sinica B, 2020, 10(5): 861-877. [8] MOREIRA R, PEREIRA DM, VALENTAO P, et al.Pyrrolizidine alkaloids: chemistry, pharmacology, toxicology and food safety[J]. International Journal of Molecular Sciences, 2018, 19(6): 1688. [9] SUN XX, XIANG E, QIU SK, et al.Research progress on toxicity of pyrrolizidine alkaloids[J]. Chinese Journal of Pharmacovigilance(中国药物警戒), 2019, 16(2): 76. [10] HABS M, BINDER K, KRAUSS S, et al.A balanced risk-benefit analysis to determine human risks associated with pyrrolizidine alkaloids(PA)-the case of herbal medicinal products containing St. John's wort extracts (SJW)[J]. Nutrients, 2017, 9(7): 717. [11] YANG M, RUAN J, FU PP, et al.Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity[J]. Chem Biol Interact, 2016, 243: 119-126. [12] ZHAO FH, HOU XT, HAO EW, et al.Chemical constituents,toxicology and pharmacological effect of momordicae semen[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2020, 26(3): 222-235. [13] YU HL, WANG W, WU H, et al.Effect of processing on lectin protein of four toxic traditional Chinese medicines of Araceae[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2019, 44(24): 5398-5404. [14] ZHENG K, ZHONG XF, ZHANG H.Advances in research on constituents and pharmacological effects of Artemisia Argyi essential oil[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2020, 26(18): 224-234. [15] MA HY, WU JJ, GE GB, et al.Research progress on metabolism and toxicity of aristolochic acid in vivo[J]. Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology(世界科学技术-中医药现代化), 2019, 21(2): 182-189. [16] LIU L, YU HL, WANG KL, et al.Effects of toxic fractions of Euphorbiae Ebracteolatae Radix on toxicity of mice intestinal tract and colon aquaporins expression level before and after vinegar processing[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2018, 43(12): 2516-2521. [17] ZHANG ZT, JIAN XX, DING JY, et al.Further studies on structure-cardiac activity relationships of diterpenoid alkaloids[J]. Natural Product Communications, 2015, 10(12): 2075-2084. [18] TANG CH, XIAO X, DUAN HZ, et al.Research progress on the mechanism of aconitine induced central neurotoxicity[J]. Guangxi Medical Journal(广西医学), 2018, 40(20): 2448-2451. [19] ZHAO Y, BU Q, ZHOU Y, et al.Mechanism study of Aconitum induced neurotoxicity in PC12 cells: involvement of dopamine release and oxidative damage[J]. Neurotoxicology, 2010, 31(6): 752-757. [20] WANG L.Central neurotoxicity of aconitine and intervention of Shuanghuanglian[D]. Wengzhou: Wenzhou Medical University, 2014. [21] LI TF, GONG N, WANG YX.Ester hydrolysis differentially reduces aconitine-induced anti-hypersensitivity and acute neurotoxicity: involvement of spinal microglial dynorphin expression and implications for aconitum processing[J]. Frontiers in Pharmacology, 2016, 7: 367. [22] WANG L, ZHAO GJ, LI MF, et al.Brain injury mechanism of acute aconitine poisoning and the intervention effect of Baicalin[J]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care(中国中西医结合急救杂志), 2014, 21(4): 289-293. [23] LI LP, TU MJ, YANG X, et al.The contribution of human OCT1, OCT3, and CYP3A4 to nitidine chloride-induced hepatocellular toxicity[J]. Drug Metabolism and Disposition, 2014, 42(7): 1227-1234. [24] CHEN SP, YANG L, FENG J.Nitidine chloride inhibits proliferation and induces apoptosis in ovarian cancer cells by activating the Fas signalling pathway[J]. International Journal of Pharmaceutics, 2018, 70(6): 778-786. [25] LIU LM, XIONG DD, LIN P, et al.DNA topoisomerase 1 and 2 A function as oncogenes in liver cancer and may be direct targets of nitidine chloride[J]. Journal of Thoracic Oncology, 2018, 53(5): 1897-1912. [26] LI C, CHEN YC, ZENG QQ, et al.Accumulation of nitidine chloride in rat heart and its mechanism[J]. Acta Pharmaceutica Sinica(药学学报), 2019, 54(5): 913-918. [27] ZAN K, ZHANG R, LI YL, et al.Research progress of quality control of pyrrolizidine alkaloids in Farfarae Flos[J]. Chinese Journal of Pharmaceutical Analysis(药物分析杂志), 2021, 41(5): 753-759. [28] REN LW, ZHENG XJ, LI W, et al.Historical cognition and evaluation of Tripterygium Wilfordii toxicity[J]. Herald of Medicine(医药导报), 2021, 40(5): 637-641. [29] MENG TQ, MA HB.Research progress on reproductive toxicity mechanism of Tripterygium wilfordii[J]. Chinese Archives of Traditional Chinese Medicine(中华中医药学刊), 2020, 38(3): 196-198. [30] ZHAO YT, WU SP, HU CL, et al.Reviews on chemical compositions and pharmacological effect of gelsemium elegans[J]. Chinese Journal of Experimental Traditional Medical Formulae(中国实验方剂学杂志), 2019, 25(3): 200-210. [31] SUN MX, XU QQ, MENG WQ, et al.Research progress on pharmacological and toxicological mechanism of Gelsemium elegans[J]. Journal of Toxicology(毒理学杂志), 2020, 34(4): 336-341. [32] SHUKLA B, SAXENA S, USMANI S, et al.Phytochemistry and pharmacological studies of Plumbago zeylanica L.: a medicinal plant review[J]. Clinical Phytoscience, 2021, 7(1): 34. [33] CHEN SF, ZHAO XP, YU SM, et al.Study on acute toxicity of Yao medicine baihuadan before and after processing[J]. Journal of Medicine & Pharmacy of Chinese Minorities(中国民族医药杂志), 2017, 23(2): 65-66. [34] WANG JM, WU XH, LIU C, et al.Study on toxicity, compatibility and processing of Huangyaozi[J]. Lishizhen Medicine and Materia Medica Research(时珍国医国药), 2019, 30(10): 2480-2482. |