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20 August 2019, Volume 16 Issue 8 Previous Issue    Next Issue

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Metabonomics Reveals that Aristolochic Acid I Affects β-oxidation of Fatty Acids, Glucose Metabolism and the TCA Cycle in the Mice Liver CUI Yuan, LI Haishan, SONG Naining, LI Bin, SUI Feng, LI Yingfei, GUO Jiabin, JIA Qiang, LI Hua, GAO Yue, SHEN Guolin 2019, 16(8): 449-466.  Abstract ( 459 )   PDF (2207KB) ( 361 )   Objective To reveal the differential endogenous substances generated via hepatic metabolism stimulated by aristolochic acid I and the most relevant metabolic pathways using metabonomics combined with molecular biotechnology. Furthermore, to systematically explore the mechanism by which aristolochic acid I affects hepatic metabolic functions in mice. Methods Six-week-old male C57BL/6 mice were randomly divided into four groups of different doses of aristolochic acid I: 0.2, 2, 10 and 20 mg·kg-1, and one untreated control group. The drug was administrated by gavage, 5 days/week for 4 consecutive weeks. Metabonomics technology combined with physiology, pathology, molecular biology, enzymology, drug metabolism and systems biology were used to explore the mechanism by which aristolochic acid I affects hepatic metabolic functions in mice. Results Aristolochic acid I affected hepatic metabolism by promoting glycolysis in hepatocytes, improving the fatty acid uptake function of hepatocytes, inhibiting gluconeogenesis and β oxidation of fatty acid, impeding the TCA cycle, and finally leading to hepatic microenvironment metabolic disorder. Conclusion Based on metabonomics combined with bioinformatics, the mechanism by which aristolochic acid I affected hepatic metabolic functions was illuminated from a new perspective. References | Related Articles | Metrics

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Clinical Efficacy and Adverse Reaction of Torasemide Combined with Bisoprolol in the Treatment of Patients with Essential Hypertension Complicated with Systolic Heart Failure ZHANG Shengzhang, HUANG Weijian 2019, 16(8): 467-472.  Abstract ( 387 )   PDF (705KB) ( 120 )   Objective To study the clinical efficacy of torasemide combined with bisoprolol in the treatment of patients with essential hypertension complicated with systolic heart failure. Methods 134 patients with essential hypertension and systolic heart failure admitted to our hospital from May 2016 to June 2018 were enrolled in the study. According to the random number table method, control group (torasemide treatment) 67 cases and study group (torasemide combined with bisoprolol treatment) 67 cases. Blood pressure, cardiac function, biochemical parameters, clinical efficacy and adverse reactions were compared before and after treatment. Results The total effective rate of treatment in the study group (95.52%) was significantly higher than the control group (80.60%), and the difference was statistically significant (P <0.05). Before and after treatment, the systolic blood pressure, diastolic blood pressure and 24 h blood pressure variability were significantly different (P<0.05). After treatment, the systolic blood pressure, diastolic blood pressure and 24 h blood pressure variability of the study group were significantly lower than the control group, the difference was statistically significant (P<0.05). Before and after treatment, the left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD) and heart rate were significantly lower than those before treatment, and left ventricular ejection fraction (LVEF) was significantly increased. The difference was statistically significant (P<0.05). Compared with the control group, the LVEDD, LVESD and heart rate in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). Compared with before and after treatment, superoxide dismutase (SOD) was significantly increased, malondialdehyde (MDA) and brain natriuretic peptide (BNP) were significantly decreased (P<0.05). After treatment, the SOD of the study group was significantly higher than the control group, and the MDA and BNP were significantly lower than the control group (P<0.05). The incidence of adverse reactions (8.96% vs 11.94%) was not significantly different (P>0.05). Conclusion Torasemide combined with bisoprolol is effective in the treatment of essential hypertension complicated with heart failure. It is also helpful to improve cardiac function, stabilize blood pressure, inhibit oxidative stress, and have low incidence of adverse reactions and higher safety. References | Related Articles | Metrics

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Investigation and Analysis on the Status quo of Post-marketing Risk Monitoring System of TCM Formula Granules LIU Zhen, YU Jinyang, ZHOU Jie 2019, 16(8): 473-477.  Abstract ( 490 )   PDF (830KB) ( 230 )   Objective To understand the status quo of post-marketing risk monitoring system of TCM formula granules and guide enterprises to build a perfect safety monitoring system, so as to provide references for enterprises to carry out follow-up safety and effectiveness evaluations and provide basis for supervision of TCM formula granules. Methods The data were collected mainly by electronic questionnaires and supplemented by interviews, a total of 37 questions were set in the questionnaire for enterprises producing TCM formula granules, and 6 enterprises were investigated; Questionnaires for medical institutions were distributed online with 45 questions in total and 161 ones were collected. Results All six enterprises have established the organizational structure and basic system for adverse reaction monitoring. Two enterprises considered that clinical studies needed to be carried out to evaluate the safety of varieties, two tended to carry out centralized post-marketing safety monitoring, and three tended to carry out randomized controlled clinical trials. The questionnaires collected from doctors showed that doctors are currently informed of adverse reactions mainly through patients' active feedback (73.56%). For the adverse reaction monitoring methods carried out in the future, 83.90% of clinicians considered that clinical studies needed to be carried out to evaluate the safety of varieties, 56.90% of clinicians tended to carry out centralized post-marketing safety monitoring, and 51.72% of clinicians tended to carry out randomized controlled clinical trials. Conclusions Enterprises did not pay enough attention to the safety monitoring of TCM formula granules. It is suggested that enterprises should summarize and analyze the safety data of previous clinical studies, implement the systems of main responsibility and direct reporting of adverse drug reactions at the same time, and actively monitor, analyze and evaluate the adverse drug reactions. References | Related Articles | Metrics

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Detection and Evaluation of Post-marketing Safety Alert Signals for Human Papillomavirus 9-valent Vaccine Based on US Vaccine Adverse Event Reporting System (VAERS) GONG Li, PAN Lingyun, LIU Yan, JI Huanhuan, TANG Xuewen, JIA Yuntao 2019, 16(8): 478-486.  Abstract ( 718 )   PDF (938KB) ( 1784 )   Objective To detect and evaluate the post-marketing safety warning signals of separate vaccination of human papillomavirus 9-valent vaccine (9vHPV), so as to provide references for follow-up studies and vaccinations. Methods 9vHPV-related (alone) AE reports from January 2015 to December 2018 were collected from the VAERS and comprehensive standard method was adopted to detect and evaluate the safety warning signals. Results A total of 39 safety warning signals were obtained through detection, involving 14 SOCs in total, the first three signals in each class were nervous system diseases, reproductive system diseases and breast diseases, and investigations, among which, the new signals of clinical concern included irregular menstruation (PRR=12.11,χ2=48.94), amenorrhea (PRR=4.43,χ2=14.41), infertility (PRR=8.86,χ2=32.54), ovarian cyst (PRR=7.85,χ2=16.31), opsomenorrhea (PRR=8.56,χ2=17.81), menorrhagia (PRR=4.96, χ2=9.42), premature menopause (PRR=4.43,χ2=5.93), alopecia (PRR=3.02,χ2=19.27). Conclusion In this paper, comprehensive standard method was adopted to mine relevant data from VAERS and many new safety signals were detected at last, which lays a foundation for the follow-up safety studies on 9vHPV. References | Related Articles | Metrics

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Literature Review of 141 Cases of Adverse Drug Reactions Induced by Simvastatin ZHANG Xuan, GU Yunxia* 2019, 16(8): 487-491.  Abstract ( 570 )   PDF (736KB) ( 265 )   Objective To provide references for the safe and rational use of simvastatin in clinic through investigating the characteristics of adverse drug reactions (ADRs) induced by this drug. Methods Using "simvastatin", "adverse reaction" as key words to search and retrieve articles in the CNKI database, WanFang database and VIP Chiese full-text database. The literature was analyzed according to the inclusion and exclusion criteria. Results A total of 123 papers, 141 cases were included. Systems and organs mainly involved in ADRs were musculo-skeletal system disorders and liver and biliary system disorders. ADRs occurred most frequently within 90 days of medication. Conclusion It is important for clinicians and patients to make aware of simvastatin-induced ADRs. Supervision and precaution should be strengthened in the clinical use of simivastatin. References | Related Articles | Metrics

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Pharmacological Practice for One Case of Advanced Lung Cancer with Bronchial Asthma and Pulmonary Infection CAI Jiangxia, AN Linna 2019, 16(8): 492-495.  Abstract ( 364 )   PDF (668KB) ( 300 )   Objective To explore the role of clinical pharmacists in the treatment of patients with advanced lung cancer and bronchial asthma. Methods Based on one case of advanced lung cancer with severe pain and bronchial asthma, the clinical pharmacists carried out pharmaceutical care from analgesic drugs selection and evaluation, adverse reactions precaution and anti-infection drugs choice etc. Results The clinical pharmacist proposed individualized treatment, and the doctor adopted the recommendation to ensure the patient's safe use of medication, and improved the quality of life and the level of clinical drug treatment. Conclusion The collaboration of clinical pharmacists and clinicians is benefit to optimize patients' individualized treatment regimens and ensure the safety and effect of drugs from drug selection, contraindication, adverse reaction prevention etc. References | Related Articles | Metrics

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Research Progress on Toxic Material Basis and Hepatotoxicity Mechanism of Polygonum Multiflorum YU Ruili, MEN Weijie, ZHOU Kun, YU Yingli 2019, 16(8): 496-503.  Abstract ( 458 )   PDF (607KB) ( 397 )   Polygonum multiflorum is a traditional Chinese medicine with commonly clinical application. With increasing cases of Polygonum multiflorum related hepatotoxicity reported, the drug safety problem has been received more and more attention. This article reviews the toxicity characteristics of Polygonum multiflorum from the aspects of clinical cases, chemical composition and toxic material basis, and hepatotoxicity mechanism. We aim to provide a useful reference for the clinical use and mechanism research of Polygonum multiflorum. References | Related Articles | Metrics

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One Case of Allergic Reaction and Paroxysmal Supraventricular Tachycardia Induced by Rituximab Injection LI Jinwen, ZHANG Ping, LIAO Yingxi, TIAN Jixin, WANG Xiaodan, LI Shan, YAN Haihong 2019, 16(8): 504-505.  Abstract ( 424 )   PDF (576KB) ( 241 )   References | Related Articles | Metrics

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One Case of Palpitation Induced by Empagliflozin Tablets CAI Jun, JI Liwei 2019, 16(8): 506-507.  Abstract ( 463 )   PDF (525KB) ( 156 )   References | Related Articles | Metrics

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One Case of Systemic Numbness with Pain Induced by Pantoprazole Sodium for Injection SUN Lirui, GUO Qiushi, ZHANG Hongmei, TIAN Xu, ZHOU Wei 2019, 16(8): 508-508.  Abstract ( 356 )   PDF (506KB) ( 172 )   References | Related Articles | Metrics

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One Case of Acute Laryngeal Edema Induced by Oxybuprocaine Hydrochloride Gel MA Bingjie, LI Changrong, CANG Aijun 2019, 16(8): 509-510.  Abstract ( 301 )   PDF (522KB) ( 196 )   References | Related Articles | Metrics

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One Case of Severe Liver Injury Induced by Shiduqing Tablets HUANG Li, LUO Shengping 2019, 16(8): 511-512.  Abstract ( 410 )   PDF (521KB) ( 181 )   References | Related Articles | Metrics