Abstract: Objective To study the general pattern and characteristics of adverse drug reaction(ADR) induced by posterior pituitary injection to provide references for clinical rational use of the drugs. Methods 102 cases of ADR/ADE related to the posterior pituitary injection from January 2004 to June 2014 in Henan province were analyzed using retrospective study method.The drug instructions of three domestic pharmaceutical enterprises were compared. Results The main ADR/ADE damages involved gastrointestinal system(60.10%) and central nervous system (8.48%), the severe ADRs manifestations mainly covered unconsciousness, hyponatremia etc. There was no warning of hyponatremia in the drug instructions. Conclusion It should be concerned about hyponatremia induced by hypophysin, perfect the drug instruction, in order to reduce the incidence of severe ADR/ADE.

Key words: posterior pituitary injection, adverse drug reaction/event(ADR/ADE), analysis