Abstract: Objective To investigate the lung protective effects of ambroxol in children with tetralogy of fallot undergoing radical surgery. Methods From March 2012 to August 2014, a total of 61 children with tetralogy of fallot undergoing radical surgery were divided into normal observation group (n=34) and control group (n=34) randomly according to obscura envelope method. Ambroxol was applied in observation group at the end of operation, and normal saline was given in control group. The surgical case and breathing were recorded at each time point after operation. Results Compared with control group, the time of ICU, mechanical ventilation and hospitalization in observation group showed significant change after operation (P <0.05). Compared with control group, observation group showed significantly increased level of arterial partial pressure of oxygen on the third, fourth day after surgery(P <0.05). Compared with control group, observation group showed significant change of the arterial partial pressure of oxygen and oxygenation index in the first week after surgery (P <0.05). The incidence of infection in newborn in observation group showed obviously lower than those in the control group(P <0.05). Conclusion Ambroxol has a significant curative effect for lung protection in the patients after tetralogy of fallot surgery while avoiding respiratory complications, and it can be used widely in clinical work.

Key words: ambroxol, tetralogy of fallot, lung protection, efficacy