Abstract: Objective To observe the difference in procoagulant activity between living rhino horn and rhino horn by the comparative research method. Methods The procoagulant activity of the living rhino horn and traditional rhino horn was evaluated in DIC model mice by intravenous thrombin and amino caproic acid. Results The living rhino horn of 100, 200 mg·kg-1 significantly increased the number of platelets and shorten TT, PT and APTT of DIC model mice. There was no difference in procoagulant activity of traditional rhino horn and the living rhino horn at the same dose. Conclusion The procoagulant activity of living rhino horn is equal to that of the traditional rhino horn,and the living rhino horn can be used as a substitute of rhino horn.

Key words: living rhino horn, rhino horn, procoagulant activity, mice