Chinese Journal of Pharmacovigilance ›› 2011, Vol. 8 ›› Issue (4): 202-204.

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Pathologic Research on Hepatotoxicity in Mice Caused by Yangxue Shengfa Capsules

LV Li-li1, XIE Yuan-zhang1,2, QIAN Xiao-lu3, YANG Qian3, SUN Rong1   

  1. 1. Shandong Research Academy of TCM, Shandong Jinan 250014, China;
    2. Harbin University of Commerce, Heilongjiang Harbin 150000, China;
    3. Shandong University of TCM, Shandong Jinan 250355, China
  • Received:2015-08-27 Revised:2015-08-27 Online:2011-04-10 Published:2015-08-27

Abstract: Objective To investigate the pathologic injury degree of hepatotoxicity in mice induced by single administration of Yangxue Shengfa Capsules and provide pathohistological basis for its hepatotoxical injury. Methodse The pathologic changes of mice in the study on "dose-time-toxicity"relationship of hepatotoxicity caused by Yangxue Shengfa Capsules was observed with light microscope and image analysis after HE stain. Results The study on the "time-toxicity" relationship indicated that the hepatotoxicity occurred at 2h after administration and expressed obviously in the range from 6h to 24h after administration. The study on the "dose-toxicity"relationship showed that pathohistological injury of different degree can be induced by drug of (2.5~12.0)g·okg-1 and acidophilia, hyalinization, vacuolus were the main pathologic changes. Conclusion Once oral administration of Yangxue Shengfa Capsules with certain dosage may induce acute hepatotoxical injury in mice and show an obvious "dose-time-toxicity" relationship. It can cause pathologic changes such as acidophilia, hyalinization, vacuolus to hepatic cells.

Key words: Yangxue Shengfa Capsules, hepatotoxicity, pathology, "dose-time-toxicity"relationship

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