Abstract: Objective Compared adverse drug reaction of nedaplatin with other platinum agents to provide the references information in clinical application. Methods224 cases of platinum agents collected from January 2009 to December 2010 were analyzed using retrospective study method. Among them,112 used nedaplatin, 112 used other platinum agents(Cisplatin: Carboplatin :Oxaliplatin=4：2：4). ResultsThe adverse drug reaction rates of Nedaplatin and other platinum agents ware 62.5%, 66.07%,which showed no significant difference. The incidence of bone marrow restrain was higher than other platinum agents(P <0.05). Liver and kidney dysfunction was significantly lower than other platinum agents(P <0.05). There were about 95% patients could be cured and 65% ADR cases reported were severe, ADR proportions of men and women were 61.81%, 38.19%, It shows significant difference(P <0.05). The majority of reported ADR were 58~72years old. ConclusionNedaplatin is higher than the other platinum agents on bone marrow suppression, lower than the other platinum agents on liver and kidney dysfunction.

Key words: nedaplatin, cisplatin, carboplatin, oxaliplatin, adverse drug reaction