Abstract: Objective To investigate the prevalence and clinical characteristics of cutaneous adverse drug reactions (CADRs) in pediatric patients, and to give evidence-based recommendations for safe medication and rational drug use. Methods A retrospective analysis was conducted of 982 cases of CADRs reported by the Children’s Hospital Affiliated to Zhengzhou University between January 2018 and December 2024. The data collected included demographics (age and gender), clinical manifestations, culprit medications, latency periods, systemic organ involvement, therapeutic interventions, and clinical outcomes. Results Among the 982 cases of CADRs, 586 involved males, and the majority were observed in the group aged 2-11. Exanthematous drug eruptions were the dominating mild manifestations, and severe reactions included drug hypersensitivity syndrome, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Anti-infective drugs, respiratory medications, and antiepileptic drugs were identified as the predominant causative agents. Among these cases, 712 underwent symptomatic treatment with antihistamines, topical/systemic steroids, and glycerite lotion. Most of the patients achieved favorable outcomes, Most of the patients achieved favorable outcomes, while the prognosis remained unknown in 11 cases. Conclusion CADRs are usually mild in children, but some cases may progress to severe CARDs. Clinicians should give pharmaceutical care during treatment to ensure the safety of drug use.

Key words: Cutaneous Adverse Drug Reaction, Children, Anti-Infective Drugs, Antiepileptic Drugs, Antihistamines Drugs, Exanthematous Drug Eruptions