Abstract: Objective Through the clinical characteristics analysis of the liver damage caused by the combination, improve the understanding of the liver damage. MethodsTo extract 254 cases liver damage by combination from the database of Center for ADR Monitoring of Jiangsu, and analyse the clinical manifestations, laboratory examination,treatment measures, drug combination number, suspected drug classification, etc. ResultsThere are 160 cases of 2 drugs combination, 62 cases of 3 drugs combination, 26 cases of 4 drugs combination, 5 cases of 5 drugs combination, only 1 case of 6 drugs combination. The suspicious drugs inducing liver damage are mainly antituberculosis medicines(56 cases, 22.05%), antitumor medicines(47 cases, 18.50%) and traditional Chinese medicines(31 cases, 12.20%). Major clinical manifestation is the abnormal level of transaminase, etc., most of the patients can be better or cured after treatment except for 2 death cases(0.79%). ConclusionStrictly master the indications of combination, and be familiar with the drugs' ingredients, metabolic features and the like to ensure safe and rational drug use.

Key words: combination, liver damage, clinical analysis