Abstract: Objective To study one case of acute generalized exanthematous pustulosis caused by hydroxychloroquine sulfate tablets in a pregnant woman in order to provide a reference for rational clinical drug use. Methods One case of acute generalized exanthematous pustulosis caused by hydroxychloroquine sulfate tablets in a pregnant woman was analyzed. Based on association evaluation and related literature, the adverse reactions and its pathogenesis were investigated, and a treatment regimen was proposed. Results The association between hydroxychloroquine sulfate tablets and acute generalized exanthematous pustulosis was highly likely. After discontinuation of hydroxychloroquine sulfate tablets and start of corticosteroid therapy, the condition persisted. The clinical pharmacist recommended adding such medications as cyclosporine, which are relatively safe for pregnant women and fetuses, and the patient’s symptoms and indicators improved significantly. Conclusion Acute generalized exanthematous pustulosis is a rare and severe adverse reaction of hydroxychloroquine sulfate tablets. After treatment with methylprednisolone combined with cyclosporine soft capsules, the symptoms of severe drug eruption in patients can be significantly improved, ensuring the safety and effectiveness of drug use for pregnant women and fetuses.

Key words: Hydroxychloroquine Sulfate Tablets, Glucocorticoids, Ciclosporine Soft Capsules, Acute Generalized Exanthematous Pustulosis (AGEP), Pregnancy