Abstract: Objective To evaluate the clinical efficacy and adverse reaction of Edaravone injection in the treatment of acute cerebral infarction. Methods The efficacy and adverse reaction of Edaravone injection versus other drugs of control group in the treatment of acute cerebral infarction reported in 20 research papers were subjected to homogeneity test and combined test using meta-analysis. Results Homogeneity test showed that the cited studies of efficacy and adverse reaction were homogeneous with χ2=9.52, χ2=3.10(P>0.05).In combined test, the combined ORe＝3.89(95% confidence interval ranged from 3.02 to 5.02, χ2＝10.47, P ＜0.05) and combined ORs＝2.08(95% confidence interval 1.19～3.64, χ2＝2.57, P＜0.05). Conclusion Clinical efficacy of Edaravone injection is significantly better than that of other drugs in treatment of acute cerebral infarction. But the incidence of ADR induced by Edaravone injection is higher than other drugs-induced ADR.

Key words: Edaravone injection, acute cerebral infarction, efficacy, adverse reaction, meta-analysis