Abstract: Objective To investigate the hepatotoxicic effect induced by different components from Cortex Periplocae in mice. Methods Mice were administrated with water extracted and alcohol extracted components for 7 days. The general situation of mice were observed, hepatical toxicity related index and the level of ALB、ALP、TBIL in serum were detected, the hepatic tissue were examined. Results The water extracted and alcohol extracted components can cause the activity of ALT、AST in serum and hepatic tissue increased, as well as the gain in liver weight. The level of ALP、TBIL corresponding increased, however the level of ALB was reduced. All changes were aggravated in accordance with the dosages. The degree of hepatotoxicity damage caused by the alcohol extracted composition is more serious than that by the water extracted composition. Conclusion The continues administration of different components from Cortex Periplocae to mice can induce obvious hepato -toxicity injury, it not only cause the changes of liver function index, but the structural patho-logical changes of hepatic cell.

Key words: Cortex Periplocae, different components, mice, hepatotoxicity