Abstract: Objective To summarize the recent research advances in the mechanisms of action and therapeutic effects of drugs for oligoasthenospermia in combination with research findings from corresponding animal models in order to provide more targeted references for the selection of drugs, in-depth studies on mechanisms, and development of new drugs for prevention and treatment of oligoasthenospermia. Methods PubMed, CNKI, and other databases were searched particularly for literature on research progress in antioxidant stress drugs, anti-apoptosis drugs, metabolism-regulating drugs, targeted drugs, hormone-regulating drugs, and multi-target regulatory drugs of TCM using oligoasthenospermia models. The action of and research data on a range of drugs were elaborated. Results Antioxidant stress, anti-apoptosis, metabolism-regulating, targeted, hormone-regulating drugs, and multi-target regulatory drugs of TCM could all deliver distinct therapeutic effects. Some of these drugs were unusually effective at addressing critical pathological abnormalities such as oxidative stress, mitochondrial dysfunction, and apoptotic imbalance, thus significantly enhancing sperm quality. Conclusion More effort should be made to gain insights into the action mechanisms of drugs, promote the transition of more efficient and safe drugs from basic research to clinical applications in order to facilitate the prevention and treatment of oligoasthenospermia.

Key words: Oligoasthenospermia, Antioxidant Stress Drugs, Anti-Apoptosis Drugs, Sperm, Drug, Progress