Efficacy Semantic Mining and Safety Analysis of Chinese Patent Medicines for Headache

doi:10.19803/j.1672-8629.20240297

Abstract

Abstract: Objective To explore the efficacy semantics of Chinese patent medicines for headache currently on the market and to conduct a meta-analysis of safety of these medicines. Methods Based on the efficacy semantics of the above-mentioned Chinese patent medicines, an efficacy semantic network of Chinese patent medicines used for headache treatment was constructed. Meta-analysis was conducted to assess the adverse reactions of the above-mentioned Chinese patent medicines in clinic. Results The functional semantic features of Chinese patent medicines for headache focused on clearing heat, detoxification, relieving exterior syndrome, managing pain and dispelling wind. A total of 23 RCT studies were included. The results of Meta-analysis showed that Chinese patent medicines alone or combined with conventional Western medicine could reduce the incidence of adverse reactions [RR=0.46, 95 %CI (0.35,0.60), P<0.05].The incidence of adverse reactions was significantly different between patients taking Tianma Gouteng granules [RR=0.52, 95%CI (0.31,0.88), P<0.05] and those using Zaoren Anshen granules [RR=0.27, 95%CI (0.14,0.49), P<0.05]. Conclusion Chinese patent medicines for headache are different in efficacy aggregation when used to treat exogenous and internal headache, and are highly safe.

Key words: Headache, Chinese Patent Medicine, Tianma Gouteng Granules, Zaoren Anshen Granules, Efficacy Semantic Network, Safety, Meta-Analysis

CLC Number:

R969.3

LIU Yiyu, LI Yanwen, WANG Jiao, ZHOU Wenjing, PENG Yumeng, HE Wenbin, LI Zhiyong. Efficacy Semantic Mining and Safety Analysis of Chinese Patent Medicines for Headache[J]. Chinese Journal of Pharmacovigilance, 2025, 22(6): 674-679.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240297

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I6/674

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