Research Progress in Drug-Induced Hypotension

doi:10.19803/j.1672-8629.20240733

Abstract

Abstract: Objective To investigate the research progress in drug-induced hypotension and provide clinical references for its prevention. Methods The categories drugs of associated with increased hypotension risk and their mechanisms of action were analyzed, the impact of pharmacogenetic polymorphisms on hypotension risk were evaluated, and the current prevention and treatment strategies were summarized by reviewing literature and searching PharmGKB database. Results Over 250 types of drugs were identified that could induce hypotension, with cardiovascular drugs and neurological drugs as the primary high-risk categories. Drugs could induce hypotension through such mechanisms as vasodilation, cardiac suppression, and blood volume reduction. Pharmacogenetic polymorphisms could significantly influence drug metabolism and hypotensive risk. Effective prevention strategies included personalized medications, genetic testing-guided dosage adjustment, avoidance of inappropriate drug combinations, and symptomatic treatment. Conclusion Drug-induced hypotension requires increased clinical attention. Future research should prioritize the development of predictive models and targeted intervention protocols for high-risk populations.

Key words: Drug-Induced, Hypotension, Adverse Drug Reaction, Pharmacogenetic Polymorphisms, Prevention, Treatment

CLC Number:

R972
R994.11

NI Wenqi, ZHU Feng, ZHOU Shuang, CUI Yimin. Research Progress in Drug-Induced Hypotension[J]. Chinese Journal of Pharmacovigilance, 2025, 22(4): 475-480.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240733

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I4/475

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