One Case of Allergic Shock Caused by Pentoxifylline Injection in a Patient with Chronic Renal Failure

doi:10.19803/j.1672-8629.20240611

Abstract

Abstract: Objective To analyze the characteristics of anaphylactic shock caused by pentoxifylline injection and provide a reference for rational drug use in clinic. Methods One case of anaphylactic shock caused by pentoxifylline in an adult with chronic kidney disease was reported. Related literature was reviewed to find out more about pentoxifylline-caused anaphylactic shock before the causes and prevention measures were analyzed. Results Based on the patient’s manifestations and the correlations between medication and time of administration, pentoxifylline was considered to have caused anaphylactic shock. After effective anti-allergic treatment, the patient’s symptoms of anaphylactic shock were relieved. Conclusion Pentoxifylline injection may increase the risk of anaphylactic shock in patients with chronic kidney disease. Adverse reactions should be monitored during medication to promote safe and rational drug use in clinical practice.

Key words: Pentoxifylline, Injections, Anaphylactic Shock, Chronic Renal Failure, Adverse Drug Reaction

CLC Number:

R977
R994.11

CHEN Fen, WANG Suping. One Case of Allergic Shock Caused by Pentoxifylline Injection in a Patient with Chronic Renal Failure[J]. Chinese Journal of Pharmacovigilance, 2025, 22(4): 469-471.

Add to citation manager EndNote|Ris|BibTeX

URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240611

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I4/469

References

[1] JAVIER D, DOLORES MS, AINHOA G, et al.Repurposing Drugs for Highly Prevalent Diseases: Pentoxifylline, an Old Drug and a New Opportunity for Diabetic Kidney Disease[J]. Clinical Kidney Journal, 2022, 15(12): 2200-2213.
[2] CORREA DJ, FERRI MC, FERNÁNDEZ MC, et al. Pentoxifylline Ameliorates Subclinical Atherosclerosis Progression in Patients with Type 2 Diabetes and Chronic Kidney Disease: a Randomized Pilot Trial[J]. Cardiovascular Diabetology, 2024, 23(1): 314.
[3] ZAKARIA H, HAMDY AN, AHMED SAN, et al.Pentoxifylline Improves Anemia through Its Novel Effect on Hypoxia-Inducible Factor-2 Alpha in Hemodialysis Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial[J]. Postgraduate Medicine, 2024, 136(8): 847-854.
[4] CARBALLADA F, GUITIAN L, NUNEZ R, et al.Anaphylaxis Due to Pentoxifylline[J]. Journal of Investigational Allergology and Clinical Immunology, 2014, 24(6): 457-458.
[5] ZHONG SJ.One Case of Anaphylactic Shock Caused by Intravenous Infusion of Pentoxifylline[J]. Chinese Journal of Modern Applied Pharmacy(中国现代应用药学), 2004, 21(3): 229.
[6] SONG JJ, ZHOU HY.One Case of Anaphylactic Shock Caused by Injectable Pentoxifylline and Literature Review[J]. Central South Pharmacy(中南药学), 2022, 20(12): 2957-2958.
[7] PAAP CM, SIMPSON KS, HORTON MW, et al.Multiple-Dose Pharmacokinetics of Pentoxifylline and Its Metabolites During Renal Insufficiency[J]. Annals of Pharmacotherapy, 1996, 30: 724-729.
[8] BRIER ME, ARONOFF GR.Drug Prescribing in Renal Failure: Dosing Guidelines for Adults and Children[M]. Philadelphia: American College of Physicians, 2007.
[9] LI X, MA Q, YIN J, et al.A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020)[J]. Frontiers in Pharmacology, 2022, 13: 845689.
[10] ZHENG G, REN GX, ZHAO ZY.Pharmacological Mechanism and Research Advance of Pentoxifylline on Cardiovascular Disease[J]. World Clinical Drug(世界临床药物), 2020, 41(11): 905-909.
[11] LI J.Clinical Efficacy and Adverse Reactions of Pentoxifylline Injection[J]. Journal of China Prescription Drug(中国处方药), 2022, 20(5): 77-78.
[12] MI YY.Causes of Skin Pruritus in Patients with Chronic Renal Failure during Hemodialysis and Nursing Countermeasures[J].Journal of Medical Information(医学信息), 2019, 32(24): 187-188.
[13] EL-SADEK HM, AL-SHORBAGY MY, AWNY MM, et al.Pentoxifylline Treatment Alleviates Kidney Ischemia/Reper-Fusion Injury: Novel Involvement of Galectin-3 and ASK-1/JNK&ERK1/2/NF-κB/HMGB1 Trajectories[J]. Journal of Pharmacological Sciences, 2021, 7(9): 520-522.
[14] SMA B, KP A, SCBG C.Quantitative Simultaneous Determination of Pentoxifylline and Paracetamol in Drug and Biological Samples at Graphene Nanoflakes Modified Electrode[J]. Journal of The Taiwan Institute of Chemical Engineers, 2020, 107(7): 15-23.
[15] WANG CY, WANG LD, LI JB, et al.Effect of Pentoxifylline on the Improvement of Cognition Impairment in Patients with NonDemented Vascular Cognitive Impairment Based on Cerebral Blood Flow[J]. Evaluation and Analysis of Drug-Use in Hospitals of China(中国医院用药评价与分析), 2021, 21(12): 1453-1455, 1463.