Zebrafish Toxicity of Trimethylsilanol: an Introduced Impurity in Fludeoxyglucose [18F] Injection

doi:10.19803/j.1672-8629.20240571

Abstract

Abstract: Objective To explore the toxicity of trimethylsilanol, which is an impurity introduced into fludeoxyglucose [¹⁸F] injection, on zebrafish embryos and larvae. Methods The development of zebrafish embryos and larvae exposed to different concentrations of trimethylsilanol was observed by stereomicroscopy, involving teratogenic and lethal detection. The trajectory tracking system for zebrafish behavior was used to analyze the influence of trimethylsilanol on autonomous behavior of larvae. Results Trimethylsilanol led to a dose-dependent decrease of survival of zebrafish embryos and larvae, induced an increase in deformity and edema of pericardial sac in both embryos and larvae, inhibited embryo yolk sac absorption and larvae floating growth, and activated the behavior of larvae. Conclusion Trimethylsaline has not only significant developmental and cardiac toxicity on the embryos and larvae of zebrafish, but also some neural toxicity on the larvae.

Key words: Fludeoxyglucose[¹⁸F], Injection, Trimethylsilanol, Zebrafish, Development, Cardiac System, Neural System, Toxicity

CLC Number:

R915
R994

MENG Xianghui, SUN Jiabei, Li Wenlong, JIA Juanjuan, CHENG Ming, HUANG Haiwei, SHI Yaqin. Zebrafish Toxicity of Trimethylsilanol: an Introduced Impurity in Fludeoxyglucose [¹⁸F] Injection[J]. Chinese Journal of Pharmacovigilance, 2025, 22(4): 397-402.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240571

https://zgywjj.magtechjournal.com/EN/Y2025/V22/I4/397

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Zebrafish Toxicity of Trimethylsilanol: an Introduced Impurity in Fludeoxyglucose [¹⁸F] Injection

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