Research Progress in the Treatment of Advanced Non-Small Cell Lung Cancer with Aumonertinib

doi:10.19803/j.1672-8629.20240491

Abstract

Abstract: Objective To investigate the clinical efficacy of aumonertinib as the third representative epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKIs) in patients with advanced epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC). Methods The clinical efficacy of aumonertinib against advanced NSCLC with classical EGFR mutation, advanced NSCLC with T790M drug-resistant mutation, and advanced NSCLC with rare EGFR mutation as well as the research progress in combined treatment with aumonertinib to delay the occurrence of drug resistance were reviewed. Results In real-world studies, aumonertinib extended the median progression-free survival (mPFS) to 20 months in NSCLC patients with classical EGFR mutations and to 15 months in NSCLC patients with T790M resistance mutations. Aumonertinib also showed good efficacy in NSCLC patients with rare mutations. The combination therapy with aumonertinib could effectively slow down the occurrence of drug resistance. Conclusion Aumonertinib has a marked clinical effect on patients with advanced NSCLC, which can effectively improve the survival time and prognosis of patients.

Key words: Aumolertinib, Non-small Cell Lung Cancer, Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (EGFR-TKIs), Epidermal Growth Factor Receptor(EGFR), Combination Therapy, Rare Mutations, Clinical Effects, Adverse Reaction

CLC Number:

YANG Shengxi, XU Juntong, TU Wenlian. Research Progress in the Treatment of Advanced Non-Small Cell Lung Cancer with Aumonertinib[J]. Chinese Journal of Pharmacovigilance, 2025, 22(2): 235-240.

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https://zgywjj.magtechjournal.com/EN/Y2025/V22/I2/235

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