Research progress in reproductive and hepatorenal toxicological mechanisms of Tripterygium wilfordii

doi:10.19803/j.1672-8629.20240116

Abstract

Abstract: Tripterygium wilfordii (TW) is a traditional Chinese medicine for treating rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, and urinary system diseases. TW has such effects as dispelling wind and dampness, promoting blood circulation and unblocking collaterals, reducing swelling and pain, killing insects and detoxification. However, the toxic reactions to the reproductive system, liver, and kidney pose a huge obstacle to TW's clinical applications. Based on literature published over the past 3 to 5 years, the toxicological mechanisms of TW and its active ingredients (Tripterygium glycosides and Triptolide) were analyzed. TW was found to induce mitochondrial defects and apoptosis, promote oxidative stress and inflammatory reactions, activate autophagy and ferroptosis, induce metabolic disorders, and cause toxic reactions to the reproductive system, liver, and kidney. This article is expected to provide references for the toxicological research and clinical applications of TW.

Key words: Tripterygium wilfordii, Tripterygium glycosides, Triptolide, reproductive, liver, kidney, toxicology, mechanism

CLC Number:

R978
R994.11

BAI Xue, TAN Tianyang. Research progress in reproductive and hepatorenal toxicological mechanisms of Tripterygium wilfordii[J]. Chinese Journal of Pharmacovigilance, 2024, 21(10): 1192-1199.

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URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20240116

https://zgywjj.magtechjournal.com/EN/Y2024/V21/I10/1192

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