Chinese Journal of Pharmacovigilance ›› 2024, Vol. 21 ›› Issue (8): 943-945.
DOI: 10.19803/j.1672-8629.20240158

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One case of ureterolith combined with gallstone caused by Ceftriaxone sodium for injection in children

CHAO Ying1, ZHANG Xuemei2, ZHANG Chengjian2, WANG Bei1,*   

  1. 1Department of pharmacy, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing Jiangsu 211102, China;
    2Department of pediatrics, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing Jiangsu 211102, China
  • Received:2024-03-07 Online:2024-08-15 Published:2024-08-21

Abstract: Objective To explore the mechanism of ceftriaxone injection causing ureterolith and gallstone in children, and provide reference for the safe and reasonable use of ceftriaxone injection in clinical practice. Methods The diagnosis and treatment process of ureterolith and gallstone in the children after receiving treatment with ceftriaxone was analyzed. And Related literature were searched to analyze the mechanism of adverse drug reactions and clinical countermeasures. Results After 5 days of using ceftriaxone, this child developed ureterolith and gallstones. After discontinuing the use of ceftriaxone, ureterolith naturally improved. Based on the analysis of relevant literature, children may develop ureterolith and gallstone after using ceftriaxone, but most of them disappear automatically after discontinuation. Conclusion Ceftriaxone is likely to cause ureterolith and gallstone in children, which deserves more attention in clinic.

Key words: Ceftriaxone, ureterolith, gallstone, adverse drug reaction, children

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