Abstract: ObjectiveThe paper aims to study seabuckthorn polysaccharide＇s effect on blood glucose of normal mice and modeling diabetic mice by doing experiment. MethodsOn one hand, the paper tries to adopt it as a test drug and then tries to find its effects upon blood glucose of mice after they are administered with a loading dose of sucrose, glucose, maltose, and starch. On the other hand, the paper tries to observe its effects on blood sugar of hyperglycemic mice after diabetic mice model, respectively induced by alloxan and streptozotocin, which are administered intra-gastrically with different doses of seabuckthorn polysaccharide. ResultsWe find following results. One is that compared with the control group, in the glucose tolerance model group, the starch group obviously lowers their blood glucose level(P <0.01), and next to it is the sucrose group(P <0.05). The other is that compared with alloxan(streptozotocin), the high-dozed model group with seabuckthorn polysaccharide produces an obvious effect upon hyperglycemic mice after being administered for two weeks and four weeks(P <0.01, P <0.05). And the last result is that their sugar reducing rate is respectively 31.72%(33.14%) and 45.70%(43.78%), only followed by low-dozed model group(P <0.05, P <0.05), with sugar reducing rates respectively as 28.02%(27.07%) and 39.38%(36.43%). ConclusionWe draw a conclusion that seabuckthorn has a good effect upon reducing blood sugar of mice induced by alloxan and streptozotocin respectively, but hypoglycemic intensity is related to dosage.

Key words: Seabuckthorn, mice, blood sugar tolerance, diabetic animal models