Research progress in novel xanthine oxidase inhibitors and treatment of gout

doi:10.19803/j.1672-8629.20230584

Abstract

Abstract: Objective To summarize the recent progress in research on xanthine oxidase (XO) inhibitors. Methods Small molecule XO inhibitors were elaborated in terms of structural scaffold, molecular docking, activity and pharmacokinetics. Results Carboxylic acid and amide based XO inhibitors showed a favorable potential with activities comparable to those of topiroxostat, which could be a hotspot for future design of XO inhibitors. Conclusion It is expected that further structural optimization of carboxylic acids and amides will lead to the discovery of more effective XO inhibitors.

Key words: xanthine oxidase, inhibitors, gout, hyperuricemia, carboxylic acids, amides, purines, uric acid-lowering drugs

CLC Number:

R977

JIN Shengju, ZHOU Miao, ZHANG Jianing, GE Gonghui, ZHANG Tingjian, MENG Fanhao. Research progress in novel xanthine oxidase inhibitors and treatment of gout[J]. Chinese Journal of Pharmacovigilance, 2024, 21(2): 223-228.

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https://zgywjj.magtechjournal.com/EN/Y2024/V21/I2/223

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