Abstract: Objective To explore the methods of managing severe adverse drug reactions of acute anaphylactic shock induced by mannatide. Methods Two cases of severe adverse drug reactions of acute anaphylactic shock induced by mannatide, a drug often used for diseases caused by hypoimmunity, were analyzed. Results Both patients suffered from anaphylactic shock within about 10 minutes of intravenous drip of mannatide. The patients' symptoms were ameliorated after such symptomatic treatments as the withdrawal of mannatide, use of anti-allergic drugs and oxygen inhalation. Conclusion Clinicians are to learn about the allergic history and medical history of patients before the medication with mannatide injection. Patients should be closely monitored during medication. The skin test and use of anti-allergic drugs before administration could help prevent adverse drug reactions.

Key words: mannatide, allergy, adverse drug reaction, skin test