Abstract: Objective To find out the clinical features of adverse drug reactions(ADRs) induced by propofol injection and provide reference for its clinically safe application. Medhods The Chinese electronic databases of the Chinese National Knowledge Infrastructure and Wangfang data during 1994-2010 were searched with composite terms of propofol and adverse drug reaction or allergy, etc. All literatures associated with adverse drug reaction of propofol injection were reviewed and screened. Propofol injection-induced ADR cases were analyzed statistically in respects of demographic distribution, types of disease and allergic history, organs and systems involved in ADR, clinical manifestations and ADR outcomes, etc. Results Thirty-two of Available literatures were retrieved and total 37 adverse drug reaction cases were collected. Of all screened cases, the incidence in female patients was 2.4 times higher than that in male patients, 70.27% of those was occurred in the population of ages15-44. The lesions of adverse drug reaction involved primarily in circulation system and respiratory system, the corresponding constitutive ratio were 26.88% and 26.34%, respectively. The allergic shock happened to 16 patients(43.24%) with one death. 23(62.16%) of adverse drug reactions occurred within 30 min and the fastest adverse drug reaction case occurred about 5 seconds after injection.Conclusion The clinical manifestations of propofol induced-ADRs are complicated and diversified. The frequency of allergic shock induced by propofol injection is high and severe cases can lead to death. Clinical physicians should pay more attention to the patient and ensure patient safety after propofol injection is administered.

Key words: propofol injection, drug adverse reaction(ADR), analysis