Chinese Journal of Pharmacovigilance ›› 2019, Vol. 16 ›› Issue (5): 289-292.

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Literature Analysis of 376 Cases of Adverse Drug Reactions Induced by Ceftriaxone Sodium for Injection

WANG Fang1, LI Yonghui1,*, GUO Ruifeng1, QIU Zhihong2, LIU Xinxin1   

  1. 1 Center for Drug Monitoring and Evaluation of Hebei, Hebei Shijiazhuang 050090, China;
    2 Department of Pharmacy, Hebei People's Hospital, Hebei Shijiazhuang 050051, China
  • Received:2018-05-15 Revised:2019-06-11 Online:2019-05-20 Published:2019-06-11

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Abstract: Objective To understand the adverse reactions induced by ceftriaxone sodium for injection, and explore the regularity and characteristics of its occurrence, in order to provide a basis for safe and reasonable medication in clinic. Methods CNKI, WANFANG and VIP database were retrieved from January 2007 to June 2017, and 376 case reports of adverse drug reactions induced by ceftriaxone sodium were analyzed retrospectively. Results The incidence of ADR was related to solvent, combination, age, allergic history and alcohol-drinking history. Attention should be paid to the severe ADR that occured within 1 minute and delayed ADR. The risk warning of anaphylactic shock, gallstones and urinary calculi was insufficient in the drug instructions. Drug overdosage was a high risk factor for stones. Conclusion We should try to use sodium chloride as solvent, infuse alone, monitor children medication, be alert to the delayed ADR, pay attention to serious and new ADR, and take effective measures to prevent ADR.

Key words: ceftriaxone sodium for injection, adverse drug reaction, literature review

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