Abstract: Objective To investigate the occurrence of adverse reactions induced by ibuprofen in children in our hospital, so as to provide evidence for rational drug use in clinic. Methods 105 cases of adverse drug reactions in children treated with ibuprofen in our hospital from 2000 to 2018 were collected and analyzed according to sex, age, drugs, adverse reactions types and clinical manifestations. Results The adverse drug reactions of ibuprofen were related to dosage, course of treatment and combined use of drugs. Allergic reaction was the main clinical manifestation, and anaphylactic shock could occur. Conclusion Attention should be paid to the adverse drug reactions of ibuprofen in children, especially in children aged 0~6 years, and rational use of ibuprofen should be strictly in accordance with the labelling.

Key words: children, ibuprofen, adverse drug reaction(ADR)