Analysis of Adverse Drug Reaction Case Reports Induced by Cardiovascular Drugs Based on WHOART

Abstract

Abstract: Objective To analyze the occurrence of adverse drug reactions (ADRs) induced by cardiovascular drugs in China and the possible influencing factors of their severity. Methods 1 201 case records of ADRs induced by cardiovascular drugs were obtained from National Science Data Sharing Platform for Population and Health. Based on Martindale: the Complete Drug Reference and WHOART, the ADR symptoms were extracted and cleaned by Jieba. Other fields were normalized simultaneously, and the patients' genders, ages, routes of administration and so on in ADR records were statistically analyzed. Results In all records, male patients were slightly more than female patients and mostly aged 50~79 years; ADRs induced by intravenous administration were the most common and occurred within 10 minutes of administration; the main ADR symptoms were chest tightness. Traditional Chinese medicines were the most common drugs which induced ADRs, followed by anti-arrhythmic drugs. Most ADRs were mild and the route of administration had a significant effect on the severity of ADRs. Conclusion The method proposed in this study could effectively analyze the ADRs induced by cardiovascular drugs, and clinical medical staffs should strengthen the monitoring of ADRs induced by cardiovascular drugs, ensure rational clinical use and standardize the safety of cardiovascular drug use.

Key words: WHOART, cardiovascular drugs, adverse drug reaction, analysis, case report

CLC Number:

R994.11

LIN Xin, GUO Jinjing, REN Huiling. Analysis of Adverse Drug Reaction Case Reports Induced by Cardiovascular Drugs Based on WHOART[J]. Chinese Journal of Pharmacovigilance, 2019, 16(3): 157-163.

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