Analysis of Characteristics and Mechanism of Blood System Adverse Drug Reactions Induced by Proton Pump Inhibitors

Abstract

Abstract: Objective To explore the mechanism and characteristics of adverse drug reactions(ADRs) induced by proton pump inhibitors(PPIs) in the blood system, so as to provide a reference for rational clinical use of drugs. Methods Blood system ADR cases induced by PPIs which were reported in main medical journals published from 2000 to 2017 were collected by retrieving CNKI, Weipu and Wanfang databases and were analyzed. Results In 87 patients, males and elderly patients have the higher ratios of ADR in the blood system, and commonly occured within one week after the treatment. Omeprazole may have the highest ratios of blood system ADR, mainly including leukopenia, granulocytopenia, thrombocytopenia, and so on. Conclusion Great importance should be attached to the blood system ADR induced by PPIs in the clinic, and the blood should be monitored in time to ensure the medication safety of patients.

Key words: proton pump inhibitor, blood system, adverse reactions

CLC Number:

R994.11

MAO Jiaojiao, PAN Jie. Analysis of Characteristics and Mechanism of Blood System Adverse Drug Reactions Induced by Proton Pump Inhibitors[J]. Chinese Journal of Pharmacovigilance, 2019, 16(2): 119-122.

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