Abstract: Objective To evaluate the status of therapeutic drug monitoring of vancomycin in our hospital based on Therapeutic Drug Monitoring of Vancomycin of China, so as to provide the basis for clinical rational and effective use of vancomycin. Methods According to the Therapeutic Drug Monitoring of Vancomycin recommendation, all discharged cases data of the use of vancomycin in the hospital from July 2016 to December 2016 were retrospectively investigated. We analyzed the relationship between blood drug concentration of vancomycin and timing of collecting serum, and the relationship between the risk of acute kidney injury with the body mass index, renal function state and a critical condition in the group without blood drug concentration monitoring of vancomycin. Results There were 408 cases that used vancomycin． 107 cases were monitored blood drug concentration, the monitoring percentage is 26.2%. All these patients were monitored 197 times,of which 76 (38.58%) times of blood sampling in 48~72 h after dosing. 301 cases who used vancomycin were not monitored blood drug concentration, among which 51 cases (16.94%) of obese patients, 36 cases(11.96%) of renal insufficiencypatients, 86 cases (28.57%) of APACHE II score more than 20. But these patients should be monitored blood drug concentration of vancomycin. Conclusion The condition of vancomycin monitoring of blood drug concentration has a gap between our hospitaland guidelines recommendation, especially for obesity, renal insufficiency, and severe illness, we should strengthen the monitoring, to ensure the effectiveness of vancomycin use and to reduce the occurrence of kidney toxicity.

Key words: guideline, vancomycin, therapeutic drug monitoring, status evaluation