Formulation and Research of Guidelines for Risk Assessment of Pesticide Residues in Traditional Chinese Medicine

doi:10.19803/j.1672-8629.2021.07.11

Abstract

Abstract: Objective To provide route and reference for the research of pesticide risk assessment in TCM. Methods The risk assessment procedure of pesticide residues in TCM includes four steps: hazard identification, hazard characterization, exposure assessment and risk description. The common methods of pesticide risk assessment were summarized, and the research route and the selection of important parameters of pesticide risk assessment methods in TCM were discussed in this paper. Results The risk assessment system of pesticide residues in accordance with the use characteristics of TCM was gradually established, and the guiding principles of risk assessment were formed. Conclusion The risk assessment of pesticide residues in traditional Chinese medicine (TCM) is of great significance for the formulation of pesticide residue standards and safety supervision.

Key words: risk assessment, traditional Chinese medicine, pesticide residues, guidelines, cumulative assessment, deterministic approach

CLC Number:

R971.4R969.1

WANG Ying, ZHANG Lei, ZUO Tiantian, SHEN Mingrui, JIN Hongyu, MA Shuangcheng. Formulation and Research of Guidelines for Risk Assessment of Pesticide Residues in Traditional Chinese Medicine[J]. Chinese Journal of Pharmacovigilance, 2021, 18(7): 645-648.

References

[1] Zhang CZ, Liu XJ, Wu CF, et al.Advance sin risk assessment of pesticide residue[J]. Jiangsu Journal of Agricultural Sciences(江苏农业学报), 2010, 26(6): 1424-1428.
[2] Wang Y, Jin HY, Jiang YB, et al.Census of pesticide residues and suggestions for control in traditional Chinese medicine[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2014, 39(5): 807-811.
[3] Xiao JJ, Xu X, Wang F, et al.Analysis of exposure to pesticide residues from Traditional Chinese Medicine[J]. Journal of Hazardous Materials, 2019(365): 857-867.
[4] Wang Y, Wang Z, Yue ZH, et al.Risk assessment of pesticide residues in domestic ginsengs[J]. China Journal of Chinese Materia Medica(中国中药杂志), 2019, 44(7): 1327-1333.
[5] Zuo TT, Wang Y, Zhang L, et al.Guideline of risk assessment of exogenous harmful residues in traditional Chinese medicines[J]. Chinese Journal of Pharmaceutical Analysis(药物分析杂志), 2019, 39(10): 1902-1907.
[6] Wang XW, Chou HY, Zhang ZH, et al.Diet exposure assessment methods in food[J]. Acta Agriculturae Zhejiangensis(浙江农业学报), 2012, 24(4): 733-738.
[7] Wu XL, Zhao B, Qi XJ, et al.Review on the risk assessment methods for chemical pollutants in food[J]. Preventive Medicine(预防医学), 2020, 32(7): 682-685.
[8] Yang GL, Chen C, Wang Q, et al.Risk assessment for combined exposure of multiresidue of pesticides[J]. Chinese Journal of Pesticide Science(农药学学报), 2015, 17(2): 119-127.
[9] Yuan YW, Wang J, Ye ZH.Exposure estimate and cumulative exposure estimate on pesticide residues from dietary[J]. Food Science(食品科学), 2008,338(1): 374-378.
[10] Yang GL, Chen C, Wang Q, et al.Construction of risk assessment procedure for combined exposure of multiresidue of pesticides[J]. Quality and Safety of Agro- Products(农产品质量与安全), 2018(3): 12-20.
[11] Wang YBN, Liu AD, Li JW, et al.Consumption investigation of traditional Chinese medicine among adult residents in 11 provinces and cities[J]. Chinese Pharmaceutical Affairs(中国药事), 2017, 31(6): 666-672.
[12] Zuo TT, Jin HY, Zhang L, et al.Innovative health risk assessment of heavy metals in Chinese herbal medicines based on extensive data[J]. Pharmacological Research, 2020(159): 104987.
[13] Jin SG, Survey report on nutrition and health status of Chinese residents (10): 2002 nutrition and health data set(中国居民营养与健康状况调查报告之十: 2002年营养与健康状况数据集)[M]. Beijing: People's Health Publishing House, 2008.
[14] Wang Y, Jin HY, Sui HX, et al.Analysis of pesticide residues in wolfberry and Dietary exposure risk assessment[J]. Chinese Pharmaceutical Journal(中国药学杂志), 2018, 53(3): 182-186.
[15] Qiao XW.Some considerations on dietary exposure assessment of pesticide residues in food[J]. Chinese Journal of Pesticide Science(农药学学报), 2020, 22(5): 727-733.
[16] State health and Family Planning Commission of the People's Republic of China, Ministry of agriculture of the people's Republic of China. Maximum residue limits of pesticides in food: GB2763-2019(食品中农药最大残留限量: GB2763-2019)[S]. Beijing: China Standards Press, 2019.
[17] Zhang L, Liu ZP.The choices and usage of some important parameters in risk assessment of food chemicals[J].Chinese Journal of Food Hygiene(中国食品卫生杂志), 2015, 27(3): 308-311.
[18] Chen C, Li Y, Chen ZJ, et al.Assessment of acute dietary exposure to pesticide residues in EPA[J]. Chinese Agricultural Science Bulletin(中国农学通报), 2009, 25(16): 69-74.
[19] WHO (World Health Organization). Inventory of evaluations performed by the joint meeting on pesticide residues (JMPR) [EB/OL]. (2012-01-02)[2017-03-01]. http://apps.who.int/ pesticide-residues-jmpr-database.html.
[20] Zou XN, Tan H, Zhong YP, et al.Risky assessment of food safety and its application[J]. Guizhou Agricultural Sciences(贵州农业科学), 2008(3): 169-172.
[21] State health and Family Planning Commission of the people's Republic of China. Acute oral toxicity test: GB 15193.3-2014
(急性经口毒性试验: GB15193.3-2014)[S]. Beijing: China Standards Press, 2014.
[22] Chinese Pharmacopoeia Commission.Pharmacopdeia of People's Republic of China: Volume IV. 2020 edition(中华人民共和国药典:四部2020年版)[S]. Beijing: China Medical Science and Technology Press, 2020.
[23] Zhang L, Li FQ, Liu ZP.Cumulative risk assessment method and application of chemicals in food[J]. Chinese Journal of Food Hygiene(中国食品卫生杂志), 2011, 23(4): 378-382.