Systematic Review and Meta-analysis of Adverse Effects

Abstract

Abstract: Nowadays, the evaluation of drug adverse effects has gained more and more attention. Due to the inconsistent incidence of adverse effects reported by different studies and the wide variety of drugs, it is not scientific to draw a conclusion based on single clinical studies or large surveys. Systematic review / meta-analysis comprising all available studies can provide better evidence on drug adverse effects in general. This assay is to introduce the basic concept and the characteristics of drug adverse effects and the steps of making a systematic review/ meta-analysis for evaluating the drug adverse effects, involving the proposal of questions, searching strategy, methods of pooling of data, and the modification and update of review.

Key words: adverse effect, systematic review, meta-analysis

CLC Number:

R994.11

FENG Xue, LIU Jian-ping, CHEN Wei. Systematic Review and Meta-analysis of Adverse Effects[J]. Chinese Journal of Pharmacovigilance, 2017, 14(5): 298-303.

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