Abstract: Objective To investigate the drugs leading to drug-induced pulmonary diseases and discuss their clinical characteristics, so as to provide reference for rational drug use in the clinic. Methods Literatures of drug-induced pulmonary diseases publicly reported in domestic medical journals from 1979 to 2015 were collected and analyzed statistically. Results A total of 227 relevant articles were identified, which reported 433 cases of drug-induced pulmonary diseases, involving cardiovascular drugs, anticancer drugs, non-steroidal anti-inflammatory drugs, anti-microbial agents and traditional Chinese medicine injections. The main syndromes were asthma, interstitial pneumonia, drug-induced pulmonary edema, pulmonary fibrosis,etc. Most cases improved after drug withdrawal and symptomatic treatment, but 53 patients died. Conclusion A variety of drugs can induce drug-related lung damages. It is necessary to be vigilant, so as to reduce the incidence of adverse reactions.

Key words: drug-induced pulmonary diseases, adverse reaction, safe drug use