Abstract: Objective To establish the animal model of hepatic fibrosis with the basis of etiology and pathogenesis of hepatic fibrosis and the clinical practice of traditional Chinese medicine (TCM), which is stable and reliable and is suitable for the activity and efficacy of TCM.Methods References in the last decades at home and abroad about the animal model of hepatic fibrosis were collated, summarized and analyzed. Results There are many medical pathologicals of hepatic fibrosis at present, though the mechanisms and applications of models are different. There are also many problems in the study of the efficacy evaluation and pathological mechanism of TCM, such as sensitivity, reliability and stability of the model. Conclusion We should research hepatic fibrosis animal model which is more in line with actual clinical syndromes and TCM theory on the basis of guidance of Chinese medicine theory, TCM clinical manifestations of hepatic fibrosis, combining modern etiology and pathogenesis study, in order to study the nature of hepatic fibrosis and liver medicine to provide better tools for evaluation,.

Key words: hepatic fibrosis, animal model, efficacy evaluation of TCM