Research progress on hesperetin and its derivatives against fibrosis

doi:10.19803/j.1672-8629.2022.05.24

Abstract

Abstract: Hesperetin is a dihydro flavonoid compound derived from young fruits of the Citrus in Rutaceae family,which has a significant inhibitory effect on the fibrosis process of lung, liver, kidney and heart. However, due to the complex mechanism of hesperetin inhibiting fibrosis, it is still in the experimental research stage and needs further study. This article explores the mechanism of hesperetin on pulmonary fibrosis, hepatic fibrosis, renal fibrosis, heart fibrosis and other diseases from the aspects of anti-inflammatory, anti-oxidative stress, promoting cell apoptosis, inhibiting cell activation and proliferation, and inhibiting cell epithelial-mesenchymal transition, and expounds that hesperetin and its derivatives inhibit fibrosis Research progress. It will provide some reference and help for the future development of hesperetin as a targeted fibrosis drug and how to improve the utilization of hesperetin.

Key words: hesperetin, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, heart fibrosis

CLC Number:

R994.11
R961

WAN Wei, CHANG Jun, ZHU Du, CHEN Wen. Research progress on hesperetin and its derivatives against fibrosis[J]. Chinese Journal of Pharmacovigilance, 2022, 19(5): 579-584.

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