Abstract: Objective To investigate the characteristics and influence factors of adverse drug reactions (ADR) induced by statins. Methods 190 reports of adverse drug reactions induced by statins, collected from Sichuan ADR Monitoring Center via National ADR Monitoring System from Jan. 2004 to Jun. 2012 were analyzed. Results Skin le sions, muscle lesions, gastrointestinal system and liver function failure were the most common adverse reaction of statins, some nervous system and blood system abnormals followed. The serious adverse reactions frequently involved liver dysfunction. Conclusion Lipid -lowering drugs should be strictly regulated by dose and time -limit, to avoid any overtime or overdose medication. To emphasize the return consultation and follow-ups of out-patients may reduce the incidence of adverse reaction in statins.

Key words: statins, lipid-lowering drugs, adverse drug reaction, statistical analysis