Abstract: Objective To analyze the general characteristics of adverse drug reaction induced by fosfomycin sodium, provide reference for rational drug use in clinic. Methods Using "fosfomycin sodium" and "adverse drug reaction" as the keywords, searched the cases of the adverse drug reaction induced by fosfomycin sodium which were reported from Jan 1980 to Jan 2013. The data were analyzed in terms of occurrence time, original disease, clinical manifestation, prognosis, et al. Results There were 33 publications including 97 cases. Skin and appendages disorders were with the highest incidence, followed by the respiratory system disorders, systematic disorders and cardiovascular disorders. The main clinical manifestations were pruritus, rash, dyspnea, sense of suppression in the chest, et al. Most of adverse drug reactions got right after drug withdrawal and symptomatic treatment. Conclusion The adverse drug reactions induced by fosfomycin sodium were low, and prognosis was well. Attention should be paid to the adverse drug reactions induced by fosfomycin sodium in clinic, and the monitoring of medication should also be strengthened to ensure the safe medication.

Key words: fosfomycin, adverse drug reaction, literature analysis