Abstract: Objective To study the general pattern and characteristics of adverse drug reaction(ADR) induced by magnesium sulfate injection to provide references for clinical rational use of the drugs. Methods 157 cases of ADR/ADE related to the magnesium sulfate injection from January 2010 to June 2013 in Henan province were analyzed using retrospective study method. Results Most of the patients taking the drug were female whose age was 20~39(69.43%). The cases occurred within 30 minutes accounted for 68.79% of the total. The main ADR/ADE damages were systemic damage ( 36. 36 % ) and gastrointestinal system damage ( 25. 17 % ) . The ADR manifestations mainly covered nausea, vomiting, flushing, dizziness and palpitation, etc. Conclusion The ADR/ADE induced by magnesium sulfate injection had been recorded in Henan ADR monitoring database. It is suggested that we should strengthen the ADR monitoring of magnesium sulfate injection, and improve the drug instruction, in order to reduce the incidence of severe ADR/ADE.

Key words: magnesium sulfate injection, adverse drug reaction/event(ADR/ADE), analysis