Abstract: According to the recent Results of clinical trials and literatures, some problems were discussed in this paper, such as the co-administrasion of cardiovascular drugs, drug adverse reactions and the rational use of medicines. Meanwhile, we discussed the rational time and dosage that patients should pay attention to,especially for some special patients, like female patients and old age patients whose physiologic function has some difference with others. Some questions about how to choose the best cardiovascular drugs and dosage were discussed also. The aim is to improve the rationality of clinical medication and reduce the ADR risk.

Key words: cardiovascular drugs, co-administrasion, adverse drug reaction(ADR)