Chinese Journal of Pharmacovigilance ›› 2010, Vol. 7 ›› Issue (2): 70-72.

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Influence of Different Components on Acute Toxicity of Rhizoma Menispermi in mice

YANG Qian1,2, LUO Dong1,2, ZHAO Yan3, SUN Rong1,*   

  1. 1Shandong Academy of Chinese Medicine, Shandong Jinan 250014, China;
    2Shandong University of Traditional Chinese Medicine, Shandong Jinan 250355, China;
    3Center for Drug Reevaluation, SFDA, Beijing 100045, China
  • Received:2016-02-19 Revised:2016-02-19 Online:2010-02-08 Published:2016-02-19

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Abstract: To study the acute toxicity of different components of Rhizoma Menispermi, the acute toxic study on all-components,water extract and alcohol extract of Rhizoma Menispermi to mice were developed in this paper. Ig all-components,water extract and alcohol extract of Rhizoma Menispermi to mice and the MLD, MTD, LD50 were tested differently by the classic Methods of acute toxicity. The Results showed that the MLD of all-components is 15.96g·kg-1;the MTD of water extract is 92.12g·kg-1 and the LD50 of alcohol extract is75.116 g·kg-1. We can draw a Conclusion from the Results that the size order of acute toxicity of different components in Rhizoma Menispermi is alcohol extra ct>water extract. The all-components is atoxic on the whole. It can provide experimental basis for clinical safe medication.

Key words: Rhizoma Menispermi, all-components, water extract, alcohol extract, acute toxicity

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