Abstract: Objective To investigate one case of vulvar ulcer suspected to be caused by the recombinant human papillomavirus quadrivalent (types 6,11,16,18) vaccine (4v hpv vaccine) so as to provide a reference for safe vaccination. Methods The clinical data of one patient who developed vulvar ulcer after receiving the 4v hpv vaccine was analyzed while related literature was reviewed to identify the possible causes and manage this adverse reaction. Results The patient used to be healthy with no related medical history. Vulvar ulcer was considered to be an adverse reaction associated with the 4v hpv vaccine. After anti-infection treatment, the patient improved and was discharged. Conclusion After vaccination with the 4v hpv vaccine, monitoring of vaccine-related adverse reactions is essential, and immediate therapeutic interventions are recommended in the event of vulvar ulcers.

Key words: Human Papillomavirus Vaccine, Quadrivalent, Vaccination, Vulvar Ulcer, Adverse Reaction