Abstract: Objective To investigate the safety of drugs with similar structure to disulfiram and combined with drugs containing ethanol as excipients. Methods One case of disulfiram-like reactions after using cefoperazone sodium and sulbactam sodium for injection combined with deslanoside injection was analyzed before the disulfiram-like reactions were explored based on literature at home and abroad. Results The patient was given intravenous drips of deslanoside injection, cefoperazone sodium and sulbactam sodium for injection. After 12 minutes, the patient began to show a mild increase of heart rate, chills, facial flushing, sweating and other symptoms. After withdrawal of medication and symptomatic treatment, these symptoms were alleviated. Conclusion The combination of ethanol-containing excipients and cephalosporin antibiotics may lead to disulfiram-like reactions that, in severe cases, can cause disturbance of consciousness, fainting, shock and death. Clinicians should be cautious in using excipients containing ethanol in high-risk groups, make careful assessments before medication and monitor patients in order to prevent serious disulfiram-like reactions.

Key words: Cefoperazone Sodium and Sulbactam Sodium, Deslanoside, Disulfiram-Like Reaction, Adverse Drug Reaction