One Case of Anaphylactic Shock Caused by Purified Protein Derivative of Tuberculin

doi:10.19803/j.1672-8629.20250185

Abstract

Abstract: Objective To investigate the characteristics and mechanisms of anaphylactic shock caused by a purified protein derivative of tuberculin (TB-PPD) in order to ensure the safety of medication. Methods The clinical data of a 10-year-old patient was studied, who had experienced anaphylactic shock following an intradermal injection of TB-PPD during a tuberculin skin test. The underlying mechanisms were analyzed based on related literature. Results According to correlation analysis, it was concluded that the allergic shock experienced by the patient was likely caused by TB-PPD. After anti-allergic and symptomatic treatment, the patient recovered. Conclusion Anaphylactic shock has rapid onset and may be life-threatening, which is a rare but severe adverse reaction linked to TB-PPD. Close monitoring of patients is essential during treatment to prevent this adverse reaction.

Key words: Purified Protein Derivative of Tuberculin (TB-PPD), Tuberculin, Anaphylactic Shock, Adverse Drug Reaction

CLC Number:

R978
R994.11

LI Jiaxi, LEI Xiaotian, ZHAO Ke, NIU Li, SUN Yang, ZHONG Huaile, GUO Hao. One Case of Anaphylactic Shock Caused by Purified Protein Derivative of Tuberculin[J]. Chinese Journal of Pharmacovigilance, 2026, 23(3): 340-342.

Add to citation manager EndNote|Ris|BibTeX

URL: https://zgywjj.magtechjournal.com/EN/10.19803/j.1672-8629.20250185

https://zgywjj.magtechjournal.com/EN/Y2026/V23/I3/340

References

[1] WHO. Tuberculosis Resurges as Top Infectious Disease Killer[EB/OL]. (2024-10-29)[2025-02-15]. https://www.who.int/zh/news/item/29-10-2024-tuberculosis-resurges-as-top-infectious-disease-killer.
[2] WHO. Tuberculosis[EB/OL]. (2024-10-29)[2025-02-12]. https://www.who.int/zh/news-room/fact-sheets/detail/tuberculosis.
[3] LEI J, LIU GT, TIAN XM, et al.Analysis of BCG-PPD and TB-PPD Screening Test Results in 2933 University Freshmen[J]. Journal of Ningxia Medical University(宁夏医科大学学报), 2021, 43(8): 854-856.
[4] Beijing Simcere Sanroad Biological Products Co.,Ltd.. Instructions for Purified Protein Derivative of Tuberculin(TB-PPD)[EB/OL]. (2023-11-10)[2025-02-23]. http://www.sanroadbio.com/attached/upload/file/20231127/6383667473699450631940361.jpg.
[5] WHO. Brief Overview of Anaphylaxis as an Adverse Event Following Immunization (AEFI) andPractical Guidance on its Identification, Case Management and Response in a Primary Care Setting[EB/OL]. (2021-07-01)[2025-03-21]. https://www.who.int/publications/i/item/9789240028704.
[6] GU YH.One Case Report of Anaphylaxis Following a PPD Skin Test[J]. Jiangsu Journal of Preventive Medicine(江苏预防医学), 1998(2): 59.
[7] SUN YQ, ZZHANG SH.The PPD Test with the Result that Anaphy-lactic Shock 1 Example[J]. Chinese Journal of the Practical Chinese with Modern Medicine(中华实用中西医杂志), 2005, 18(17): 798-798.
[8] LI T, WWANG XJ, FENG Z.Comparison of the Chinese Method for Evaluating the Causal Relationship of Adverse Drug Reactions, the WHO-UMC Assessment Method, and the naranjo Scale Assessment Method[J]. Chinese Journal of Clinical Rational Drug Use(临床合理用药), 2025, 18(17): 145-149.
[9] NARANJO CA, BUSTO U, SELLERS EM, et al.A Method for Estimating the Probability of Adverse Drug Reactions[J]. Clin Pharmacol Ther, 1981, 30(2): 239-245.
[10] LI X, MA Q, YIN J, et al.A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020)[J]. Front Pharmacol, 2022, 13: 845689.
[11] DU WX, ZHAO AH, WANG GZ, et al.Overview of Tuberculin Products Development[J]. Chinese Journal of Antituberculosis(中国防痨杂志), 2019, 41(10): 1080-1083.
[12] ZHANG YY, XXIAO ZP, WANG CS, et al.Study on the Clinical Safety of Purified Protein Derivative of Tuberculin (TB-PPD)[J]. Contemporary Medicine(当代医学), 2014(29): 115-116.
[13] GAO ZD, LI YY, LI B, et al.Comparative Analysis of the Skin Test Responses Using 2IU and 5IU Tuberculin Purified Protein Derivatives Performed Respectively on Two Arms of Same Body[J]. Capital Journal of Public Health(首都公共卫生), 2022, 16(1): 4-8.
[14] WANG SQ, YE L, JIN ML. Advances in Omalizumab Treatment for IgE-mediated Food Allergies[J/OL]. Chinese Journal of Clinical Medicine(中国临床医学), (2025-03-11)[2025-08-01]. https://link.cnki.net/urlid/31.1794.R.20250311.1046.002.
[15] ZHANG P.Clinical Application Value of Interferon Gamma Release Assay in the Diagnosis of Pulmonary Tuberculosis[J]. Chinese Journal of Antituberculosis(中国防痨杂志), 2024, 46(S2): 74-75.