Abstract: Objective To explore the risk factors, clinical characteristics, and treatment strategies related to severe psychiatric disorders induced by the combination of meropenem and voriconazole so as to provide a reference for safe medications. Methods One case of psychiatric abnormality after the combined use of meropenem and voriconazole was analyzed, and the possible mechanism and management strategies for the adverse reactions were explored with reference to literature. Results A patient with postoperative rectal cancer complicated by pulmonary infection, abdominal infection and bloodstream infection developed severe psychiatric disorders after the combined use of meropenem and voriconazole. These two drugs were considered to be the likely cause of the adverse reaction. After discontinuation of the drugs and symptomatic treatment with antipsychotic medications, the patient’s psychiatric symptoms disappeared. Conclusion Clinical use of meropenem and voriconazole demands attention to risk factors related to neurotoxicity. In case of adverse reactions involving the central nervous system, prompt drug discontinuation and symptomatic management are required.

Key words: Meropenem, Voriconazole, Antibiotics, Infection, Mental Disorders, Central Nervous System Toxicity, Adverse Drug Reaction