Abstract: Objective To explore the adverse reaction-peripheral neuropathy-induced by the combination of moxifloxacin hydrochloride tablets and voriconazole tablets so as to provide a reference for rational clinical drug use. Methods The process of diagnosis and treatment, risk factors, possible mechanisms, and therapeutic strategies for peripheral neuropathy in an elderly patient following the combination of moxifloxacin and voriconazole were analyzed. Results Based on the correlation assessment, peripheral neuropathy was considered to have been caused by the combined use of moxifloxacin and voriconazole. After discontinuation of medication and symptomatic treatment, the patient's lower limb activity improved enough to enable him to walk on his own. Conclusion While moxifloxacin is commonly combined with voriconazole for pulmonary aspergillosis, the present case suggests that their concurrent use may induce peripheral neuropathy. It is recommended that this combination be avoided if possible. Prudence and pharmacovigilance are essential to safe medication.

Key words: Moxifloxacin, Voriconazole, Peripheral Neuropathy(PN), Adverse Drug Reaction